Aldolly Ahmed, Karaja Saja, Arab Hazem, Alsaffaf Yousef, Takkem Saleh
Faculty of Medicine, Hama University, Hama, Syria.
Cardiology Department, Hama National Hospital, Hama, Syria.
J Investig Med High Impact Case Rep. 2025 Jan-Dec;13:23247096251331840. doi: 10.1177/23247096251331840. Epub 2025 May 8.
Congenitally corrected transposition of the great arteries (ccTGA) is a complex cardiac abnormality that represents less than 1% of all congenital heart defects. It is characterized by a unique pathophysiology involving both atrioventricular and ventriculoarterial discordance and may occur with or without cardiac abnormalities such as ventricular septal defects, pulmonary stenosis, or tricuspid valve anomalies. A man in his 20s presented with a 3-week history of mild dyspnea during strenuous activities. The patient was diagnosed with isolated ccTGA based on electrocardiogram and echocardiogram findings. However, as a long-term complication of ccTGA, the patient exhibited mild tricuspid regurgitation, mild mitral regurgitation, and right ventricular hypertrophy. The dyspnea was explained by the failing systemic right ventricle. Despite his cardiac anomaly, the patient leads a normal lifestyle, with ongoing monitoring to ensure optimal management of his condition. ccTGA is even rarer in the absence of additional cardiac abnormalities, and its diagnosis could be delayed due to being asymptomatic. Patients must avoid risk factors and that could potentially aggravate their condition. Regular surveillance is imperative for the early detection of potential complications.
先天性矫正型大动脉转位（ccTGA）是一种复杂的心脏异常，在所有先天性心脏缺陷中占比不到1%。其特点是具有独特的病理生理学，涉及房室和心室动脉不一致，可能伴有或不伴有心脏异常，如室间隔缺损、肺动脉狭窄或三尖瓣异常。一名20多岁的男性在剧烈活动时出现了3周的轻度呼吸困难病史。根据心电图和超声心动图检查结果，该患者被诊断为孤立性ccTGA。然而，作为ccTGA的一种长期并发症，该患者出现了轻度三尖瓣反流、轻度二尖瓣反流和右心室肥厚。呼吸困难是由功能衰竭的体循环右心室引起的。尽管存在心脏异常，但该患者仍过着正常的生活方式，并持续接受监测以确保对其病情进行最佳管理。在没有其他心脏异常的情况下，ccTGA更为罕见，并且由于无症状，其诊断可能会延迟。患者必须避免可能加重病情的危险因素。定期监测对于早期发现潜在并发症至关重要。
