Santos Cláudia, Lobo Kaike, Campos Pedro, Oliveira Larah, da Silva Vithor Ely Bortolin
Department of Neurosurgery, FG University Center, Brumado, Brazil.
Department of Neurosurgery, State University of Pará, Belém, Brazil.
Neurosurg Rev. 2025 May 9;48(1):409. doi: 10.1007/s10143-025-03555-5.
Recurrent lumbar disc herniation (RLDH) is a common and debilitating condition. Surgical options include repeat Discectomy alone or with spinal Fusion, but the optimal approach remains debated. This meta-analysis evaluates their comparative efficacy. Following PRISMA guidelines, we conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) comparing these procedures. Searches in PubMed, Embase, and Cochrane databases yielded four RCTs with 596 patients. Primary outcomes included the Visual Analog Scale (VAS), the Japanese Orthopaedic Association (JOA) scale, and re-recurrence rates. A random-effects model assessed pooled effects, and heterogeneity was measured with I² statistics. Fusion significantly reduced VAS scores for low back pain compared to Discectomy alone (SMD - 1.91; 95% CI [-3.69, -0.13]; p = 0.04; I²=98%). However, VAS scores for lower limb pain (MD -0.33; 95% CI [-0.70, 0.03]; p = 0.07; I²=95%) and JOA scores (MD 0.41; 95% CI [-0.38, 1.20]; p = 0.31; I²=0%) showed no significant differences between groups. The Fusion group had a lower re-recurrence rate (RR 0.10; 95% CI [0.02, 0.54]; p = 0.008; I²=0%) and reduced postoperative instability (RR 0.11; 95% CI [0.02, 0.63]; p = 0.01; I²=0%). Findings suggest that spinal Fusion enhances stability and reduces re-recurrence but does not significantly improve functional recovery or all pain aspects. Treatment choice should consider clinical factors, patient preferences, and surgeon expertise.
复发性腰椎间盘突出症(RLDH)是一种常见且使人衰弱的病症。手术选择包括单独重复椎间盘切除术或联合脊柱融合术,但最佳方法仍存在争议。本荟萃分析评估了它们的相对疗效。遵循PRISMA指南,我们对比较这些手术的随机临床试验(RCT)进行了系统评价和荟萃分析。在PubMed、Embase和Cochrane数据库中进行检索,获得了四项包含596例患者的RCT。主要结局包括视觉模拟量表(VAS)、日本骨科协会(JOA)量表以及再次复发率。采用随机效应模型评估合并效应,并使用I²统计量测量异质性。与单独椎间盘切除术相比,融合术显著降低了腰痛的VAS评分(标准化均数差 -1.91;95%置信区间[-3.69, -0.13];p = 0.04;I² = 98%)。然而,下肢疼痛的VAS评分(平均差 -0.33;95%置信区间[-0.70, 0.03];p = 0.07;I² = 95%)和JOA评分(平均差0.41;95%置信区间[-0.38, 1.20];p = 0.31;I² = 0%)在两组之间无显著差异。融合术组的再次复发率较低(风险比0.10;95%置信区间[0.02, 0.54];p = 0.008;I² = 0%),且术后不稳定情况减少(风险比0.11;95%置信区间[0.02, 0.63];p = 0.01;I² = 0%)。研究结果表明,脊柱融合术可增强稳定性并降低再次复发率,但并未显著改善功能恢复或所有疼痛方面。治疗选择应考虑临床因素、患者偏好和外科医生的专业技能。