Plain-language commentary: 2-year findings from the FIREFLEYE next study looking at how well aflibercept injected into affected eyes in babies with retinopathy of prematurity works and how safe it is compared with laser treatment.
作者信息
Stahl Andreas, Nakanishi Hidehiko, Lepore Domenico, Wu Wei-Chi, Azuma Noriyuki, Jacas Carlos, Athanikar Aditya, Vitti Robert, Chu Karen, Iveli Pablo, Zhao Fei, Schlief Sarah, Leal Sergio, Schmelter Thomas, Miller Thomas, Köfüncü Evra, Fielder Alistair
机构信息
Department of Ophthalmology, University Medicine Greifswald, Ferdinand Sauerbruch Straße, Greifswald 17475, Germany.
Division of Neonatal Intensive Care Medicine, Department of Advanced Medicine, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan.
出版信息
Ther Adv Ophthalmol. 2025 May 7;17:25158414251321730. doi: 10.1177/25158414251321730. eCollection 2025 Jan-Dec.
Abstract
摘要
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1
Plain-language commentary: 2-year findings from the FIREFLEYE next study looking at how well aflibercept injected into affected eyes in babies with retinopathy of prematurity works and how safe it is compared with laser treatment.通俗易懂的评论：FIREFLEYE next研究的2年结果，该研究观察了向患有早产儿视网膜病变的婴儿患眼注射阿柏西普的效果以及与激光治疗相比的安全性。
Ther Adv Ophthalmol. 2025 May 7;17:25158414251321730. doi: 10.1177/25158414251321730. eCollection 2025 Jan-Dec.
2
Intravitreal Aflibercept vs Laser Therapy for Retinopathy of Prematurity: Two-Year Efficacy and Safety Outcomes in the Nonrandomized Controlled Trial FIREFLEYE next.玻璃体内阿柏西普与激光治疗早产儿视网膜病变：FIREFLEYE 下一步非随机对照试验的两年疗效和安全性结果。
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Effect of Intravitreal Aflibercept vs Laser Photocoagulation on Treatment Success of Retinopathy of Prematurity: The FIREFLEYE Randomized Clinical Trial.玻璃体内注射阿柏西普与激光光凝治疗早产儿视网膜病变的疗效比较：FIREFLEYE 随机临床试验。
JAMA. 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564.
4
Systemic exposure to aflibercept after intravitreal injection in premature neonates with retinopathy of prematurity: results from the FIREFLEYE randomized phase 3 study.早产儿视网膜病变经玻璃体腔内注射后脉络膜血管生成抑制剂阿柏西普的全身暴露：FIREFLEYE 随机 3 期研究结果。
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Comparison of the Efficacy Between Intravitreal Aflibercept and Laser Photocoagulation in the Treatment of Retinopathy of Prematurity.玻璃体内注射阿柏西普与激光光凝治疗早产儿视网膜病变的疗效比较
J Pediatr Ophthalmol Strabismus. 2020 Jan 1;57(1):54-60. doi: 10.3928/01913913-20191104-01.
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Comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurity.阿柏西普与贝伐单抗治疗1型早产儿视网膜病变的比较。
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Intravitreal aflibercept injection in Indian eyes with retinopathy of prematurity.玻璃体腔内注射阿柏西普治疗早产儿视网膜病变的印度人群研究。
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Correction: Systemic exposure to aflibercept after intravitreal injection in premature neonates with retinopathy of prematurity: results from the FIREFLEYE randomized phase 3 study.更正：玻璃体内注射阿柏西普后早产视网膜病变早产儿的全身暴露情况：FIREFLEYE随机3期研究结果
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Efficacy of Aflibercept Treatment and Its Effect on the Retinal Perfusion in the Oxygen-Induced Retinopathy Mouse Model of Retinopathy of Prematurity.抗血管内皮生长因子治疗在早产儿视网膜病变氧诱导模型中的疗效及其对视网膜灌注的影响。
Ophthalmic Res. 2021;64(1):91-98. doi: 10.1159/000509380. Epub 2020 Jun 12.
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Efficacy of intravitreal aflibercept monotherapy in retinopathy of prematurity evaluated by periodic fluorescence angiography and optical coherence tomography.通过定期荧光血管造影和光学相干断层扫描评估玻璃体内阿柏西普单药治疗早产儿视网膜病变的疗效。
Int Ophthalmol. 2019 Oct;39(10):2161-2169. doi: 10.1007/s10792-018-1040-x. Epub 2018 Nov 26.
本文引用的文献
1
Intravitreal Aflibercept vs Laser Therapy for Retinopathy of Prematurity: Two-Year Efficacy and Safety Outcomes in the Nonrandomized Controlled Trial FIREFLEYE next.玻璃体内阿柏西普与激光治疗早产儿视网膜病变：FIREFLEYE 下一步非随机对照试验的两年疗效和安全性结果。
JAMA Netw Open. 2024 Apr 1;7(4):e248383. doi: 10.1001/jamanetworkopen.2024.8383.
2
Role of Anti-Vascular Endothelial Growth Factor (Anti-VEGF) in the Treatment of Retinopathy of Prematurity: A Narrative Review in the Context of Middle-Income Countries.抗血管内皮生长因子（Anti-VEGF）在早产儿视网膜病变治疗中的作用：基于中等收入国家背景的叙述性综述
Pediatric Health Med Ther. 2023 Feb 15;14:59-69. doi: 10.2147/PHMT.S391591. eCollection 2023.
3
Effect of Intravitreal Aflibercept vs Laser Photocoagulation on Treatment Success of Retinopathy of Prematurity: The FIREFLEYE Randomized Clinical Trial.玻璃体内注射阿柏西普与激光光凝治疗早产儿视网膜病变的疗效比较：FIREFLEYE 随机临床试验。
JAMA. 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564.
4
Complications of retinopathy of prematurity treatment.早产儿视网膜病变治疗的并发症。
Curr Opin Ophthalmol. 2021 Sep 1;32(5):475-481. doi: 10.1097/ICU.0000000000000783.
5
Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): an open-label randomised controlled trial.雷珠单抗与激光治疗用于治疗极低出生体重早产儿视网膜病变（RAINBOW）：一项开放标签随机对照试验。
Lancet. 2019 Oct 26;394(10208):1551-1559. doi: 10.1016/S0140-6736(19)31344-3. Epub 2019 Sep 12.
6
Screening Examination of Premature Infants for Retinopathy of Prematurity.早产儿视网膜病变的筛查检查。
Pediatrics. 2018 Dec;142(6). doi: 10.1542/peds.2018-3061.
7
Long term refractive and structural outcome following laser treatment for zone 1 aggressive posterior retinopathy of prematurity.激光治疗1区侵袭性早产儿视网膜病变后的长期屈光和结构转归
Oman J Ophthalmol. 2014 Sep;7(3):116-9. doi: 10.4103/0974-620X.142592.
8
Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity.玻璃体内注射贝伐单抗治疗 3 期及以上早产儿视网膜病变的疗效。
N Engl J Med. 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374.
9
Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial.早产儿视网膜病变早期治疗（ETROP）随机试验的最终结果。
Trans Am Ophthalmol Soc. 2004;102:233-48; discussion 248-50.
10
Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial.早产儿视网膜病变治疗的修订指征：早产儿视网膜病变早期治疗随机试验结果
Arch Ophthalmol. 2003 Dec;121(12):1684-94. doi: 10.1001/archopht.121.12.1684.
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