Chamkouri Hossein, Si Jianmin, Chen Peng, Ni Haiyong, Bragin Denis E, Ahmadlouydarab Majid, Niu Chaoshi, Chen Lei
School of Materials Science and Engineering, Hefei University of Technology, Hefei, Anhui, China.
Department of Neurosurgery, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, China.
Interdiscip Med. 2024 Jul;2(3). doi: 10.1002/inmd.20240013. Epub 2024 Jul 25.
Photobiomodulation (PBM) has emerged as a rapidly growing and innovative therapeutic method for various illnesses in recent years. Due to the irreversible nature of Parkinson's disease (PD), it has proven challenging to impede or postpone the progression of the disease. Despite research on pharmacological approaches to halt neuronal degeneration, the viability of these techniques has been called into doubt due to apprehensions over potential side effects and the ethical implications associated with the utilization of embryonic cell transplantation. Hence, developing an innovative therapeutic approach to halting neuronal degeneration and safeguarding neurons from this neurodegenerative disorder is imperative. This review examines the pathogenesis, challenges, and limitations of conventional PD therapies, allowing a closer examination of PBM's distinctive approach within this medical context. Delving into PBM's therapeutic mechanisms in the cells, the effects of different wavelengths on cell therapies in PD patients, and considerations for patient care administration to overcome traditional challenges, this study offers insights into its potential as a promising avenue for PD management.
近年来,光生物调节(PBM)已成为一种快速发展且创新的针对各种疾病的治疗方法。由于帕金森病(PD)的不可逆性,已证明阻碍或延缓该疾病的进展具有挑战性。尽管对阻止神经元变性的药理学方法进行了研究,但由于对潜在副作用以及与胚胎细胞移植相关的伦理问题的担忧,这些技术的可行性受到了质疑。因此,开发一种创新的治疗方法来阻止神经元变性并保护神经元免受这种神经退行性疾病的影响势在必行。本综述探讨了传统PD疗法的发病机制、挑战和局限性,以便在这一医学背景下更深入地研究PBM的独特方法。通过深入研究PBM在细胞中的治疗机制、不同波长对PD患者细胞治疗的影响以及为克服传统挑战而进行患者护理管理的考虑因素,本研究深入探讨了其作为PD管理的有前景途径的潜力。
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