Hong Namgue
Department of Pre-medical Science, College of Medicine, Dankook University, Cheonan, 31116 Republic of Korea.
Biomed Eng Lett. 2019 Jun 12;9(3):359-366. doi: 10.1007/s13534-019-00115-x. eCollection 2019 Aug.
Photobiomodulation (PBM) is a rapidly growing as an innovative therapeutic modality for various types of diseases in recent years. Neuronal degeneration is irreversible process and it is proven to be difficult to slow down or stop the progression. Pharmacologic approaches to slow neuronal degeneration have been studied, but are limited due to concerns about the side effects. Therefore, it is necessary to develop a new therapeutic approach to stabilize neuronal degeneration and achieve neuronal protection against several neurodegenerative diseases. In this review, we have introduced several previous studies showing the positive effect of PBM over neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and different types of epilepsy. Despite excellent outcomes of animal researches, not many clinical studies are conducted or showed positive outcome of PBM against neurodegenerative disease. To achieve clinical application of PBM against neurodegenerative disorder, determination of exact mechanism and establishment of effective clinical protocol seems to be necessary.
近年来，光生物调节作用（PBM）作为一种针对各类疾病的创新治疗方式，正迅速发展。神经元变性是一个不可逆的过程，事实证明，减缓或阻止其进展很困难。人们已经对减缓神经元变性的药理学方法进行了研究，但由于对副作用的担忧，这些方法存在局限性。因此，有必要开发一种新的治疗方法来稳定神经元变性，并实现针对多种神经退行性疾病的神经元保护。在这篇综述中，我们介绍了几项先前的研究，这些研究表明PBM对神经退行性疾病如阿尔茨海默病、帕金森病和不同类型的癫痫具有积极作用。尽管动物研究取得了出色的成果，但针对神经退行性疾病进行的PBM临床研究并不多，或者显示出积极的结果。为了实现PBM在神经退行性疾病中的临床应用，确定确切机制并建立有效的临床方案似乎是必要的。
