MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Int J Mol Sci. 2024 Jan 28;25(3):1625. doi: 10.3390/ijms25031625.
Neurodegenerative diseases involve the progressive dysfunction and loss of neurons in the central nervous system and thus present a significant challenge due to the absence of effective therapies for halting or reversing their progression. Based on the characteristics of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), which have prolonged incubation periods and protracted courses, exploring non-invasive physical therapy methods is essential for alleviating such diseases and ensuring that patients have an improved quality of life. Photobiomodulation (PBM) uses red and infrared light for therapeutic benefits and functions by stimulating, healing, regenerating, and protecting organizations at risk of injury, degradation, or death. Over the last two decades, PBM has gained widespread recognition as a non-invasive physical therapy method, showing efficacy in pain relief, anti-inflammatory responses, and tissue regeneration. Its application has expanded into the fields of neurology and psychiatry, where extensive research has been conducted. This paper presents a review and evaluation of studies investigating PBM in neurodegenerative diseases, with a specific emphasis on recent applications in AD and PD treatment for both animal and human subjects. Molecular mechanisms related to neuron damage and cognitive impairment are scrutinized, offering valuable insights into PBM's potential as a non-invasive therapeutic strategy.
神经退行性疾病涉及中枢神经系统中神经元的进行性功能障碍和丧失，因此由于缺乏有效治疗方法来阻止或逆转其进展，这是一个重大挑战。基于神经退行性疾病（如阿尔茨海默病（AD）和帕金森病（PD））的特征，这些疾病潜伏期长且病程长，因此探索非侵入性物理治疗方法对于缓解这些疾病以及确保患者生活质量得到改善至关重要。光生物调节（PBM）使用红色和红外光进行治疗，通过刺激、愈合、再生和保护受伤、退化或死亡的组织来发挥作用。在过去的二十年中，PBM 作为一种非侵入性物理治疗方法已得到广泛认可，在缓解疼痛、抗炎反应和组织再生方面显示出疗效。其应用已扩展到神经病学和精神病学领域，在这些领域进行了广泛的研究。本文对 PBM 在神经退行性疾病中的研究进行了综述和评估，特别关注了最近在 AD 和 PD 治疗中的应用，包括动物和人类研究。对与神经元损伤和认知障碍相关的分子机制进行了深入研究，为 PBM 作为一种非侵入性治疗策略的潜力提供了有价值的见解。
