Shackelford P G, Granoff D M, Nahm M H, Scott M G, Suarez B, Pandey J P, Nelson S J
Pediatr Res. 1985 Aug;19(8):846-9. doi: 10.1203/00006450-198508000-00014.
Concentrations of IgG1, IgG2, and total IgG were measured by a solid phase radioimmunoassay in sera from 36 healthy adults and 114 healthy children. As expected, IgG2 and total IgG had a positive correlation with age in children. In addition to age, several other factors were associated with significant differences in serum subclass concentrations. Female children had higher concentrations of IgG1 than males, and black subjects had significantly higher concentrations of IgG1, IgG2, and total IgG than whites. Although Km(1) and Gm(23) immunoglobulin allotypes had no relation to subclass concentrations when tested as single factors, the Km(1) allotype interacted significantly with race so that Km(1)-positive black children had higher IgG2 concentrations than other subjects. Our findings may explain, in part, recent observations of an association of the Km(1) allotype with altered immune responses of blacks to certain vaccines containing bacterial polysaccharides. In addition, our data indicate the need to control factors such as sex, race, and allotype in studies of subclass concentrations or immune responses.
采用固相放射免疫分析法测定了36名健康成年人和114名健康儿童血清中IgG1、IgG2和总IgG的浓度。正如预期的那样，儿童的IgG2和总IgG与年龄呈正相关。除年龄外，其他几个因素也与血清亚类浓度的显著差异有关。女童的IgG1浓度高于男童，黑人受试者的IgG1、IgG2和总IgG浓度显著高于白人。虽然作为单一因素测试时，Km(1)和Gm(23)免疫球蛋白同种异型与亚类浓度无关，但Km(1)同种异型与种族有显著相互作用，因此Km(1)阳性黑人儿童的IgG2浓度高于其他受试者。我们的研究结果可能部分解释了最近观察到的Km(1)同种异型与黑人对某些含细菌多糖疫苗的免疫反应改变之间的关联。此外，我们的数据表明在亚类浓度或免疫反应研究中需要控制性别、种族和同种异型等因素。
