Lau Y L, Jones B M, Ng K W, Yeung C Y
Department of Paediatrics, Queen Mary Hospital, University of Hong Kong.
Clin Exp Immunol. 1993 Feb;91(2):337-41. doi: 10.1111/j.1365-2249.1993.tb05905.x.
In order to establish normal reference ranges of serum immunoglobulin G subclasses for different age groups in Chinese, we measured the four IgG subclasses by radial immunodiffusion using polyclonal antisera in 350 normal healthy subjects (148 males and 202 females) recruited from the community. There was no significant sex difference for all the four IgG subclasses. Using Box-Cox transformation, we constructed smooth age-dependent percentile curves for the four IgG subclasses. For the 50th percentile values, the plateaus for IgG1 to IgG4 are respectively 970 mg/dl at 13 years old, 481 mg/dl at 18, 48 mg/dl at 17 and 80 mg/dl at 13. Methodology, reagents, environmental and genetic factors might be responsible for the observed difference among the various reports. The IgG2 level in our Chinese population seemed to be higher than that in Caucasians, which might account for the very low incidence of invasive Haemophilus influenzae type b disease among the Chinese. Our IgG1 level also plateaued later and at a higher level than that in other studies.
为建立中国不同年龄组血清免疫球蛋白G亚类的正常参考范围，我们采用放射免疫扩散法，使用多克隆抗血清，对从社区招募的350名正常健康受试者（148名男性和202名女性）的四种IgG亚类进行了检测。所有四种IgG亚类均无显著性别差异。我们使用Box-Cox变换，构建了四种IgG亚类的平滑年龄依赖性百分位数曲线。对于第50百分位数的值，IgG1至IgG4的平台期分别为：13岁时970mg/dl，18岁时481mg/dl，17岁时48mg/dl，13岁时80mg/dl。方法学、试剂、环境和遗传因素可能是导致各报告中观察到差异的原因。我们中国人群的IgG2水平似乎高于白种人，这可能是中国b型流感嗜血杆菌侵袭性疾病发病率极低的原因。我们的IgG1水平达到平台期的时间也较晚，且水平高于其他研究。
