血清卵泡刺激素水平和睾丸体积对非梗阻性无精子症男性睾丸取精结果的预测价值——一项回顾性队列研究
The Predictive Value of Serum Follicle-stimulating Hormone Level and Testicular Volume on the Outcome of Spermatozoa Retrieval from Testes in Men with Non-obstructive Azoospermia - A Retrospective Cohort Study.
作者信息
Thanikachalam Puvithra, Ravikuppan Gayatri, Arunkumar Sowbarnika, Pandiyan Radha, Natarajan Pandiyan
机构信息
Department of Reproductive Medicine, Obstetrics and Gynaecology, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India.
Department of Reproductive Medicine and Andrology, Chettinad Fertility Services, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India.
出版信息
J Hum Reprod Sci. 2025 Jan-Mar;18(1):38-44. doi: 10.4103/jhrs.jhrs_9_25. Epub 2025 Mar 29.
BACKGROUND
Biological parenthood in men with azoospermia can be achieved only by successful surgical spermatozoa retrieval and utilising these spermatozoa to perform intracytoplasmic spermatozoon injection. Spermatozoa retrieval from testes (SPERT) involves removing seminiferous tubules in an attempt to retrieve spermatozoa in men with non-obstructive azoospermia (NOA). Testicular volume and serum follicle-stimulating hormone (FSH) levels are considered to be markers for predicting the success of spermatozoa retrieval from the testes.
AIM
The aim of this study was to study the predictive value of serum FSH level and testicular volume on the outcome of SPERT in men with NOA.
SETTINGS AND DESIGN
It is a retrospective cohort study of 26 men with NOA who underwent SPERT from 2008 to 2024 in a university-level teaching hospital.
MATERIALS AND METHODS
The study population was divided into four groups based on the FSH levels (Group I: FSH: 2-10.9 mIU/mL [ = 10], Group II: FSH: 11-20.9 mIU/mL [ = 4], Group III: FSH: 21-30 mIU/mL [ = 8] and Group IV: FSH: >30 mIU/mL [ = 4]). A comparison of testicular volume and SPERT outcome was studied in the number of testes, in which SPERT was performed ( = 48) due to the differences in testicular volume in the same individual and also because only unilateral SPERT was performed in some patients. Patients were divided into three groups based on testicular volume (Group I: Testicular volume: 7-10 mL ( = 30), Group II: Testicular volume: 4-6 mL ( = 11) and Group III: Testicular volume: <3 mL ( = 7)].
STATISTICAL ANALYSIS USED
The collected data were analysed using Chi-square test using SPSS software.
RESULTS
Our observations showed no correlation between successful SPERT and serum FSH levels or testicular volume. Based on the serum FSH level, the success rate of SPERT was 40%, 50%, 25% and 75% in Groups I, II, III and IV ( = 0.415). Similarly, based on the testicular volume groups, the success rates were 30%, 45% and 71% in Groups I, II and III ( = 0.118).
CONCLUSION
In this study, we found that neither serum FSH level nor testicular volume could predict the success of spermatozoa retrieval using the SPERT technique in men with NOA.
背景
无精子症男性要实现生物学意义上的为人父，只能通过成功的手术取精并利用这些精子进行卵胞浆内单精子注射来达成。从睾丸取精（SPERT）涉及切除生精小管，试图从非梗阻性无精子症（NOA）男性中获取精子。睾丸体积和血清卵泡刺激素（FSH）水平被视为预测从睾丸取精成功与否的指标。
目的
本研究旨在探讨血清FSH水平和睾丸体积对NOA男性SPERT结果的预测价值。
设置与设计
这是一项对26例2008年至2024年在一所大学教学医院接受SPERT的NOA男性进行的回顾性队列研究。
材料与方法
根据FSH水平将研究人群分为四组（第一组：FSH：2 - 10.9 mIU/mL [n = 10]，第二组：FSH：11 - 20.9 mIU/mL [n = 4]，第三组：FSH：21 - 30 mIU/mL [n = 8]，第四组：FSH：>30 mIU/mL [n = 4]）。对进行SPERT的睾丸数量中的睾丸体积与SPERT结果进行比较研究，由于同一个体睾丸体积存在差异，且部分患者仅进行了单侧SPERT，所以共进行了48次SPERT。根据睾丸体积将患者分为三组（第一组：睾丸体积：7 - 10 mL [n = 30]，第二组：睾丸体积：4 - 6 mL [n = 11]，第三组：睾丸体积：<3 mL [n = 7]）。
所用统计分析方法
使用SPSS软件，采用卡方检验对收集的数据进行分析。
结果
我们的观察结果显示，SPERT成功与否与血清FSH水平或睾丸体积之间无相关性。基于血清FSH水平，第一、二、三、四组的SPERT成功率分别为40%、50%、25%和75%（P =
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