Hercz P
Acta Med Hung. 1985;42(1-2):29-39.
The role of steroid and peptide hormones in the maintenance of pregnancy and in the onset of labour was investigated in the maternal-fetoplacental system between the 28th-40th weeks of pregnancy. The data of 151 pregnant women and 108 newborns was processed, and a total of 2385 samples was studied by RIA. Results showed that between the 28th-40th week there is an increase in the prolactin level of the umbilical arterial and venous blood with a parallel increase in the cortisol level of umbilical arterial blood and a fall in the progesterone level of umbilical arterial and venous blood which between the 36th and 40th week results in a rise of the oestradiol/progesterone quotient. At the same time the oestradiol concentration rises in the maternal circulation and in case of premature labour the oestradiol/progesterone quotient attains values twice as high as those found in normal pregnancies. The alteration of the hormonal environment expedites the predominance of the mechanisms stimulating the activity of the myometrium. The hormone values in the umbilical artery and vein characteristically differ from those of the maternal serum. Thus, it may be assumed that the fetus, though being in close communication with the maternal organism, is capable of independently maintaining its hormonal environment. The results indicate that the fetus or more accurately the fetoplacental unit plays a significant part in the maintenance of pregnancy and in the initiation of labour than it has been assumed previously.
在妊娠第28至40周期间，对母胎 - 胎盘系统中类固醇和肽类激素在维持妊娠及分娩发动中的作用进行了研究。对151名孕妇和108名新生儿的数据进行了处理，通过放射免疫分析共研究了2385个样本。结果显示，在第28至40周期间，脐动脉和脐静脉血中催乳素水平升高，脐动脉血中皮质醇水平平行升高，脐动脉和脐静脉血中孕酮水平下降，在第36至40周时导致雌二醇/孕酮比值升高。同时，母体循环中雌二醇浓度升高，早产时雌二醇/孕酮比值达到正常妊娠时的两倍。激素环境的改变加速了刺激子宫肌层活动机制的主导地位。脐动脉和脐静脉中的激素值与母体血清中的激素值有显著差异。因此，可以假设胎儿虽然与母体密切相关，但能够独立维持其激素环境。结果表明，胎儿或者更准确地说胎 - 胎盘单位在维持妊娠和发动分娩中所起的作用比之前所认为的更为重要。
