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关节内注射透明质酸治疗髋骨关节炎:一项I级系统评价

Intra-articular hyaluronic acid injections for hip osteoarthritis: a level I systematic review.

作者信息

Migliorini Filippo, Pilone Marco, Mazzoleni Manuel Giovanni, Schäfer Luise, Katusic Dragana, Maffulli Nicola

机构信息

Department of Trauma and Reconstructive Surgery, University Hospital in Halle, Martin-Luther University Halle-Wittenberg, Halle, Germany.

Department of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy.

出版信息

Eur J Orthop Surg Traumatol. 2025 May 9;35(1):180. doi: 10.1007/s00590-025-04292-7.


DOI:10.1007/s00590-025-04292-7
PMID:40343507
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12064613/
Abstract

PURPOSE: The present systematic review investigated the efficacy of intra-articular hyaluronic acid (HA) viscosupplementation for hip osteoarthritis (OA) in patient-reported outcome measures (PROMs) and whether different molecular weights of HA are associated with different outcomes. METHODS: This study was conducted according to the 2020 PRISMA statement. In January 2025, PubMed, Web of Science, Google Scholar, and Embase were accessed. All the randomised controlled trials (RCTs) evaluating the efficacy of intra-articular HA injections in the hip for OA were included. RESULTS: Nine hundred and eighty-two patients (56% women, mean age 62.2 ± 4.0 years, mean follow-up 6.4 ± 2.7 months, mean BMI 27.5 ± 2.1 kg/m) were analysed. Patients receiving high molecular weight (HMW) and low molecular weight (LMW) HA showed significant improvements in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual analogue scale (VAS) scores (P < 0.05). No significant differences in VAS or WOMAC were observed among groups at 3-4 months of follow-up. However, at 4-6 months, the HMW HA group exhibited significantly lower VAS scores compared to the medium molecular weight (MMW) (mean difference, MD - 1.4, 95% CI - 2.1 to - 0.7, P < 0.0001), placebo (MD - 1.6, 95% CI - 2.1 to - 1.1, P < 0.0001), and control (MD - 1.3, 95% CI - 1.8 to - 0.8, P < 0.0001) groups. WOMAC scores at 4-6 months demonstrated that both HMW and MMW HA performed better than the control group (P < 0.0001), but no significant difference was observed between HMW and MMW (P = 1.0). CONCLUSION: Intra-articular injections of HA effectively reduce knee OA symptoms. Moreover, HMW HA performs better than MMW HA at a mean of 4-6 months of follow-up. LEVEL OF EVIDENCE: Level I, systematic review of RCTs.

摘要

目的:本系统评价研究了关节腔内注射透明质酸(HA)黏弹性补充疗法对髋骨关节炎(OA)患者报告结局指标(PROMs)的疗效,以及不同分子量的HA是否与不同结局相关。 方法:本研究按照2020年PRISMA声明进行。2025年1月,检索了PubMed、科学网、谷歌学术和Embase。纳入所有评估关节腔内注射HA治疗髋OA疗效的随机对照试验(RCT)。 结果:分析了982例患者(56%为女性,平均年龄62.2±4.0岁,平均随访6.4±2.7个月,平均BMI 27.5±2.1kg/m)。接受高分子量(HMW)和低分子量(LMW)HA治疗的患者在西安大略和麦克马斯特大学骨关节炎指数(WOMAC)和视觉模拟量表(VAS)评分上有显著改善(P<0.05)。随访3-4个月时,各组间VAS或WOMAC无显著差异。然而,在4-6个月时,与中分子量(MMW)(平均差值,MD -1.4,95%CI -2.1至-0.7,P<0.0001)、安慰剂(MD -1.6,95%CI -2.1至-1.1,P<0.0001)和对照组(MD -1.3,95%CI -1.8至-0.8,P<0.0001)相比,HMW HA组的VAS评分显著更低。4-6个月时的WOMAC评分显示,HMW和MMW HA均比对照组表现更好(P<0.0001),但HMW和MMW之间无显著差异(P = 1.0)。 结论:关节腔内注射HA可有效减轻髋OA症状。此外,在平均4-6个月的随访中,HMW HA比MMW HA表现更好。 证据级别:I级,RCT的系统评价。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a941/12064613/8393bf146d21/590_2025_4292_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a941/12064613/a17da28e9878/590_2025_4292_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a941/12064613/61974314aba4/590_2025_4292_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a941/12064613/8393bf146d21/590_2025_4292_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a941/12064613/a17da28e9878/590_2025_4292_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a941/12064613/61974314aba4/590_2025_4292_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a941/12064613/8393bf146d21/590_2025_4292_Fig3_HTML.jpg

相似文献

[1]
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[3]
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[4]
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[6]
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[10]
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本文引用的文献

[1]
No difference in the level of sports activity between single versus dual mobility total hip arthroplasty in adults: a clinical trial.

Eur J Med Res. 2025-3-28

[2]
Do all anatomic stems perform equally at long-term survival? A regional registry-based study on 12,010 total hip arthroplasty implants according to stem length and neck modularity.

J Orthop Traumatol. 2025-2-21

[3]
Intra-articular injections of hyaluronic acid versus plasma rich in growth factors (PRGF) for knee osteoarthritis: a meta-analysis of randomised controlled trials : A meta-analysis.

Orthopadie (Heidelb). 2025-3

[4]
Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis.

Biomedicines. 2025-1-13

[5]
Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis.

Arch Orthop Trauma Surg. 2024-12-18

[6]
Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Pharmaceuticals (Basel). 2024-11-20

[7]
Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis.

Eur J Orthop Surg Traumatol. 2024-11-23

[8]
Prevention of heterotopic ossification in primary total hip arthroplasty: a bone in the dark.

Eur J Orthop Surg Traumatol. 2024-12

[9]
Clinical relevance of patient-reported outcome measures in patients who have undergone total hip arthroplasty: a systematic review.

Arch Orthop Trauma Surg. 2024-11

[10]
Hyaluronan: Sources, Structure, Features and Applications.

Molecules. 2024-2-5

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