Iftikhar Muhammad Khubaib, Iftikhar Qurat Ul Ain
Islamic International Medical College, Riphah International University, Rawalpindi, Pakistan.
Heart Vessels. 2025 May 9. doi: 10.1007/s00380-025-02551-5.
Sex-based disparities in chronic heart failure (CHF) extend beyond clinical outcomes, encompassing psychological burden, self-care behaviors, and quality of life. In response to Sawatari and Niitani's recent findings, we critically examine underlying mechanisms and systemic contributors to these disparities. Drawing on evidence from psychocardiology, multimorbidity research, and sex-specific heart failure phenotypes, we argue that future investigations must adopt a biopsychosocial framework. Addressing physiologic stress responses, gendered health behaviors, and structural inequities will be vital to developing equitable, personalized CHF care.
慢性心力衰竭（CHF）中的性别差异不仅体现在临床结果上，还包括心理负担、自我护理行为和生活质量。针对泽渡和新谷最近的研究结果，我们批判性地审视了这些差异的潜在机制和系统性影响因素。借鉴心理心脏病学、共病研究和特定性别的心力衰竭表型的证据，我们认为未来的研究必须采用生物心理社会框架。应对生理应激反应、性别化的健康行为和结构性不平等对于制定公平、个性化的CHF护理至关重要。
