Guerra Patrícia, Alfaiate Daniel, Pinto Nuno, Pereira Telmo, Pereira Alexandre
Médio Tejo Local Health Unit, Rua António Gonçalves Curado nº30, Vila Nova Barquinha, 2260 - 390, Torres Novas, Portugal.
Polytechnic University of Castelo Branco, Castelo Branco, Portugal.
Sleep Breath. 2025 May 9;29(2):181. doi: 10.1007/s11325-025-03330-2.
Assess differences between hematocrit levels in a population with and without obstructive sleep apnea (OSA) and determine if these differences correlate with disease severity and/or with levels of hypoxemia.
Data was collected from patients who underwent level I polysomnography (PSG) in the sleep laboratory at Hospital Rainha Santa Isabel, Torres Novas, Portugal, between January 2018 and December 2022. The patients' medical data was analyzed and sociodemographic (gender, body mass index (BMI) and age), polysomnographic (Apnea and Hypopnea Index (AHI), mean SpO2, minimum SpO2, Oxygen Desaturation Index (ODI), T90 and T85) and laboratory data (hematocrit (HCT), hemoglobin (HGB) and erythrocyte count) were collected. Statistical analysis included one-way ANOVA with Tukey's HSD for pairwise comparisons, Pearson's correlation for associations between polysomnographic and hematological parameters, and multivariate regression to identify independent factors.
HCT levels were found to be higher in the moderate OSA group, particularly compared to the no OSA group (42.34 ± 4.09% vs 40.28 ± 2.75%), with significant differences between groups (p = 0.032). Although HCT levels were shown to be higher in the OSA group, the mean values remained within normal range, so no patient manifested erythrocytosis.
Our results suggest that moderate OSA is associated with increased HCT levels but does not seem to cause secondary erythrocytosis. Future research should further evaluate the hypoxic burden of OSA, as increased HCT may raise the risk of cardiovascular complications.
评估患有和未患有阻塞性睡眠呼吸暂停（OSA）人群的血细胞比容水平差异，并确定这些差异是否与疾病严重程度和/或低氧血症水平相关。
收集了2018年1月至2022年12月期间在葡萄牙托雷斯诺瓦斯圣伊莎贝尔女王医院睡眠实验室接受一级多导睡眠图（PSG）检查的患者的数据。分析了患者的医疗数据，并收集了社会人口统计学数据（性别、体重指数（BMI）和年龄）、多导睡眠图数据（呼吸暂停低通气指数（AHI）、平均SpO2、最低SpO2、氧饱和度下降指数（ODI）、T90和T85）以及实验室数据（血细胞比容（HCT）、血红蛋白（HGB）和红细胞计数）。统计分析包括用于两两比较的单因素方差分析和Tukey's HSD检验、用于多导睡眠图参数与血液学参数之间关联的Pearson相关性分析以及用于识别独立因素的多元回归分析。
发现中度OSA组的HCT水平较高，尤其是与无OSA组相比（42.34±4.09%对40.28±2.75%），组间存在显著差异（p = 0.032）。尽管OSA组的HCT水平较高，但平均值仍在正常范围内，因此没有患者出现红细胞增多症。
我们的结果表明，中度OSA与HCT水平升高有关，但似乎不会导致继发性红细胞增多症。未来的研究应进一步评估OSA的缺氧负担，因为HCT升高可能会增加心血管并发症的风险。
