Zhang Xiao-Bin, Zeng Yi-Ming, Zeng Hui-Qing, Zhang Hua-Ping, Wang Hui-Ling
The Second Clinical College of Fujian Medical University, No. 134, Zhongshan Bei Road, Licheng District, Quanzhou City, Fujian Province, 362001, P. R. China.
Department of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen City, Fujian Province, P. R. China.
Eur Arch Otorhinolaryngol. 2017 Jun;274(6):2505-2512. doi: 10.1007/s00405-017-4483-1. Epub 2017 Mar 9.
Currently available data regarding the blood levels of erythropoietin (EPO) in sleep apnea (SA) patients are contradictory. The aim of the present meta-analysis was to evaluate the EPO levels in SA patients via quantitative analysis. A systematic search of Pubmed, Embase, and Web of Science were performed. EPO levels in SA group and control group were extracted from each eligible study. Weight mean difference (WMD) or Standard mean difference (SMD) with 95% confidence interval (CI) was calculated by using fixed-effects or random effect model analysis according to the degree of heterogeneity between studies. A total of 9 studies involving 407 participants were enrolled. The results indicated that EPO levels in SA group were significantly higher than that in control group (SMD 0.61, 95% CI 0.11-1.11, p = 0.016). Significantly higher EPO levels were found in patients with body mass index <30 kg/m, and cardiovascular complications in the subsequent subgroup analysis (both p < 0.05). High blood EPO levels were found in SA patients in the present meta-analysis.
目前关于睡眠呼吸暂停（SA）患者促红细胞生成素（EPO）血液水平的现有数据相互矛盾。本荟萃分析的目的是通过定量分析评估SA患者的EPO水平。对PubMed、Embase和科学网进行了系统检索。从每项符合条件的研究中提取SA组和对照组的EPO水平。根据研究之间的异质性程度，使用固定效应或随机效应模型分析计算加权平均差（WMD）或标准化平均差（SMD）以及95%置信区间（CI）。共纳入9项研究，涉及407名参与者。结果表明，SA组的EPO水平显著高于对照组（SMD 0.61，95%CI 0.11 - 1.11，p = 0.016）。在随后的亚组分析中，体重指数<30kg/m²的患者以及有心血管并发症的患者中发现EPO水平显著更高（均p < 0.05）。在本荟萃分析中，SA患者存在高血EPO水平。
