Schauder S
Photodermatol. 1985 Apr;2(2):95-100.
The purpose of this study was to determine the concentration, vehicle, and UVA dose suitable for avoiding phototoxic reactions while revealing photoallergic reactions to chlorpormazine (CPZ) in photopatch testing. Photopatch tests were performed on 27 volunteers with CPZ concentrations between 0.05% and 1% in water or Plastibase with UVA doses of 4 or 7 J/cm2. Photopatch tests were also carried out on 1 patient with photoallergic contact dermatitis to CPZ and an increased UVA sensitivity. The same concentration of CPZ caused phototoxic reactions less frequently and less intensely in Plastibase than in water. The minimal phototoxic concentration of CPZ in Plastibase was 0.5% after irradiation with 4 J/cm2 and 0.1% after irradiation with 7 J/cm2. In the patient with photoallergy to CPZ, a photoallergic reaction was elicited after 0.1% CPZ in Plastibase and a UVA dose of 2 J/cm2. In testing photoallergic reactions to CPZ a concentration of 0.1% in Plastibase and a UVA dose of 4 J/cm2 or less should be used.
本研究的目的是确定在光斑贴试验中，既能揭示对氯丙嗪（CPZ）的光变态反应，又能避免光毒性反应的合适浓度、赋形剂和紫外线A（UVA）剂量。对27名志愿者进行光斑贴试验，使用浓度在0.05%至1%之间的CPZ，分别溶于水或Plastibase中，UVA剂量为4或7 J/cm²。还对1名对CPZ发生光变应性接触性皮炎且UVA敏感性增加的患者进行了光斑贴试验。相同浓度的CPZ在Plastibase中引起光毒性反应的频率和强度低于在水中。CPZ在Plastibase中的最小光毒性浓度在4 J/cm²照射后为0.5%，在7 J/cm²照射后为0.1%。在对CPZ光过敏的患者中，在Plastibase中使用0.1%的CPZ和2 J/cm²的UVA剂量后引发了光变态反应。在测试对CPZ的光变态反应时，应使用Plastibase中0.1%的浓度和4 J/cm²或更低的UVA剂量。
