Ono Kaori, Kume Yu
Graduate School of Medicine, Doctoral Course in Health Sciences, Akita University, Akita, Japan.
Akita Prefectural Center for Rehabilitation and Psychiatric Medicine, Daisen, Japan.
Psychogeriatrics. 2025 May;25(3):e70047. doi: 10.1111/psyg.70047.
Few studies have examined the characteristics of the decline in physical activity levels in Parkinson's disease (PD) patients from the perspective of a 24-h behavioural profile, including sleep.
To identify factors related to the rest and activity patterns in PD patients by assessing the Rest-Activity Rhythm.
The participants were 20 patients with Parkinson's syndrome (PS group) and 20 healthy elderly community residents (control group). The nonparametric rest-activity rhythm parameters were measured by a wristwatch-type activity monitor worn by the study subjects on the non-dominant hand continuously for at least 5 days. To assess the specific symptoms of PS in the patients, the scores on the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) were collected from the medical records.
In the PS group, a negative correlation was found between the relative amplitude and score for part I of the MDS-UPDRS, that is, non-motor symptoms (r = -0.51, p < 0.05). Additionally, binomial logistic regression analysis revealed two regression models, with Model I showing a significant association with the highest physical activity level over the 24-h profile (odds ratio, 0.96; 95% confidence interval [95% CI], 0.94-0.99; p = 0.002) and Model II showing a significant association with a fragmented rhythm (odds ratio, 1.04; 95% CI, 1.01-1.07; p = 0.004).
These results suggest that rehabilitation of PD patients should include increasing their physical activity levels while minimising intermittency of the rest and activity patterns, and that attention should be paid to non-motor symptoms in addition to motor symptoms.
很少有研究从包括睡眠在内的24小时行为特征角度，考察帕金森病（PD）患者身体活动水平下降的特点。
通过评估静息 - 活动节律，确定与PD患者休息和活动模式相关的因素。
参与者为20例帕金森综合征患者（PS组）和20名健康老年社区居民（对照组）。非参数静息 - 活动节律参数由研究对象佩戴在非优势手上的手表式活动监测仪连续测量至少5天。为评估患者PS的具体症状，从病历中收集运动障碍协会赞助修订的统一帕金森病评定量表（MDS - UPDRS）的评分。
在PS组中，相对振幅与MDS - UPDRS第一部分（即非运动症状）评分之间存在负相关（r = -0.51，p < 0.05）。此外，二项式逻辑回归分析揭示了两个回归模型，模型I显示与24小时内最高身体活动水平有显著关联（优势比，0.96；95%置信区间[95%CI]，0.94 - 0.99；p = 0.002），模型II显示与节律碎片化有显著关联（优势比，1.04；95%CI，1.01 - 1.07；p = 0.004）。
这些结果表明，PD患者的康复应包括提高其身体活动水平，同时尽量减少休息和活动模式的间歇性，并且除了运动症状外，还应关注非运动症状。
