Romine Jeff, Cullen Daniel, Galperin Eugene, Mattson Hakon, Vassalotti Joseph A, Tang Katelyn, Gordon Aliza S
Elevance Health Inc., Indianapolis, Indiana.
Icahn School of Medicine at Mount Sinai, New York, New York.
Clin J Am Soc Nephrol. 2025 Apr 4;20(6):810-819. doi: 10.2215/CJN.0000000699.
Exposure to days with higher heat indices was associated with increases in weekly utilization for a population with CKD. Higher heat indices were associated with a larger increase in kidney-related visits than all-cause utilization. Higher heat indices were associated with larger effects on kidney-related emergency department use for those least likely to have air conditioning.
Extreme heat events have lengthened, become more frequent, and increased in intensity over the past few decades, and this trend is expected to continue. Extreme heat events have been shown to be associated with increased mortality and emergency department (ED) visits.
We investigated the relationship between temperature and healthcare utilization among patients with CKD. We used panel regression models with individual and year fixed effects to evaluate how exposure to different levels of temperature (measured by heat index) was associated with changes in weekly healthcare utilization from October 1, 2015, to March 31, 2023. Data were derived from medical claims data, Parameter-Elevation Regressions on Independent Slopes Model climate data, and the Census block group of each individual. The study population was comprised of 916,886 individuals with commercial or Medicare insurance who had been diagnosed with CKD stage G3, G4, or G5. CKD was defined using diagnosis codes in medical claims and eGFR laboratory results. Exposure was the number of days in a week with a daily heat index in 5.6-degree Celsius bins.
We found that exposure to a higher heat index bin, 32.2°C–37.8°C compared with 15.6°C–21.1°C, was associated with an increase in weekly ED utilization (0.55%; 95% confidence interval [CI], 0.42% to 0.68%; < 0.001), with larger percent increases for ED visits with a heat-related primary diagnosis code (2.07%; 95% CI, 1.63% to 2.51%; < 0.001) or a kidney-related primary diagnosis code (1.37%; 95% CI, 0.56% to 2.17%; < 0.001). ED visits with a primary diagnosis code related to kidney disease were associated with a larger effect among those least likely to have access to air conditioning (2.48%; 95% CI, 0.84% to 4.13%; < 0.01). Smaller, statistically significant results were observed comparing heat indexes of 26.7°C–32.2°C to 15.6°C–21.1°C.
Exposure to heat indexes above 32.2°C was associated with greater weekly ED utilization and ED utilization with heat-related or kidney-related primary diagnosis codes.
对于慢性肾脏病(CKD)患者群体,暴露于热指数较高的日子与每周医疗利用率增加有关。与全因利用率相比,较高的热指数与肾脏相关就诊次数的增加幅度更大。对于最不可能拥有空调的人群,较高的热指数对肾脏相关急诊科就诊的影响更大。
在过去几十年中,极端高温事件持续时间延长、频率增加且强度增强,预计这一趋势将持续。极端高温事件已被证明与死亡率增加和急诊科就诊次数增多有关。
我们调查了CKD患者的温度与医疗保健利用率之间的关系。我们使用具有个体和年份固定效应的面板回归模型,以评估暴露于不同温度水平(通过热指数测量)如何与2015年10月1日至2023年3月31日期间每周医疗保健利用率的变化相关。数据来源于医疗理赔数据、独立斜率模型气候数据的参数-海拔回归以及每个个体的人口普查街区组。研究人群包括916,886名患有商业保险或医疗保险且被诊断为CKD G3、G4或G5期的个体。CKD使用医疗理赔中的诊断代码和估算肾小球滤过率(eGFR)实验室结果进行定义。暴露是指一周中每日热指数处于5.6摄氏度区间的天数。
我们发现,与15.6°C - 21.1°C相比,暴露于32.2°C - 37.8°C这一较高热指数区间与每周急诊科利用率增加相关(0.55%;95%置信区间[CI],0.42%至0.68%;P < 0.001),对于具有与热相关的主要诊断代码的急诊科就诊,百分比增加幅度更大(2.07%;95% CI,1.63%至2.51%;P < 0.001)或具有与肾脏相关的主要诊断代码的就诊(1.37%;95% CI,0.56%至2.17%;P < 0.001)。对于最不可能拥有空调的人群,具有与肾脏疾病相关的主要诊断代码的急诊科就诊影响更大(2.48%;95% CI,0.84%至4.13%;P < 0.01)。将26.7°C - 32.2°C与15.6°C - 21.1°C的热指数进行比较时,观察到较小的、具有统计学意义的结果。
暴露于高于32.2°C的热指数与每周更高的急诊科利用率以及具有与热相关或肾脏相关主要诊断代码的急诊科就诊相关。