两种抗组胺化合物（美喹他嗪、右氯苯那敏）对睡眠的影响。抗组胺药对睡眠的干扰。
Effects of two antihistaminic compounds (mequitazine, dexchlorpheniramine) on sleep. Sleep distorsion by antihistaminics.
作者信息
Bassano J L, Caille E J
出版信息
Waking Sleeping. 1979 Jan;3(1):57-61.
PMID:40345
Abstract
Twelve healthy subjects have been given mequitazine (two 10-milligramme doses a day), dexchlorpheniramine (two 12-milligramme doses a day) and a placebo for seven days, within a cross-over balanced design. If dexchlorpheniramine induces a significant sleep distortion (slowed REM sleep cycle and decreased amount of REM sleep), no similar trend occured with mequitazine, a result that could be dose or time related.
摘要
在交叉平衡设计中，12名健康受试者分别服用美喹他嗪（每日两次，每次10毫克）、右氯苯那敏（每日两次，每次12毫克）和安慰剂，为期7天。如果右氯苯那敏会引起明显的睡眠紊乱（快速眼动睡眠周期减慢和快速眼动睡眠时间减少），那么美喹他嗪则不会出现类似趋势，这一结果可能与剂量或时间有关。
Zotero 插件