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作者信息

Ejjebli Samia, Timimi Alaa Al, Ettagmouti Yassine, Benouna Ghali, Arous Salim, Drighil Abdenasser, Habbal Rachida

机构信息

Service de cardiologie, Hopital IBN Rochd ; Casablanca Maroc.

Service de cardiologie, Hopital IBN Rochd ; Casablanca Maroc.

出版信息

Ann Cardiol Angeiol (Paris). 2025 Jun;74(3):101899. doi: 10.1016/j.ancard.2025.101899. Epub 2025 May 8.

Abstract

INTRODUCTION

Hypocalcemia, though rare, can lead to heart failure with reduced ejection fraction and dilated cardiomyopathy. It may result from various etiologies, and its manifestations range from mild to life-threatening. Cardiovascular complications of hypocalcemia include QT interval prolongation, ventricular arrhythmias, and heart failure.we report a rare case of reversible hypocalcemic dilated cardiomyopathy.

CASE REPORT

We present the case of a 41-year-old woman with secondary hypoparathyroidism following thyroidectomy in 2018. She was treated with levothyroxine, calcitriol, and calcium and vitamin D supplements. Following a Covid-19 infection in May 2021, her hypoparathyroidism decompensated, leading to severe hypocalcemia, which was inadequately managed. Five months later, she presented with worsening dyspnea, orthopnea, and bilateral lower limb edema. Clinical examination revealed positive Chvostek and Trousseau's signs, indicating severe hypocalcemia. ECG showed sinus tachycardia with QT prolongation, and echocardiography revealed a dilated left ventricle with an ejection fraction (EF) of 29%. Despite normal coronary angiography, a CT scan showed bilateral pleural effusion and superior vena cava thrombosis. Laboratory findings confirmed hypocalcemia with elevated phosphorus and low parathyroid hormone levels. Intravenous calcium correction and heart failure management led to symptomatic improvement and normalization of serum calcium within one week. Echocardiography showed gradual recovery, with EF improving to 38% at 8 weeks and 57% after 6 months.

DISCUSSION

Calcium plays a critical role in cardiac contractility, and its deficiency can severely impact myocardial function. Hypocalcemia following thyroidectomy is a known complication and can worsen during systemic infections like Covid-19. While hypocalcemia-induced cardiomyopathy is reversible with proper treatment, it requires early recognition and aggressive correction. * CONCLUSION: This case highlights the importance of monitoring calcium levels in patients with hypoparathyroidism, especially in the context of systemic infections, to prevent potentially life-threatening complications like hypocalcemic cardiomyopathy. Proper diagnosis and treatment of hypocalcemia can lead to full recovery of cardiac function.

摘要

引言

低钙血症虽罕见,但可导致射血分数降低的心力衰竭和扩张型心肌病。其病因多样,表现从轻症到危及生命不等。低钙血症的心血管并发症包括QT间期延长、室性心律失常和心力衰竭。我们报告一例罕见的可逆性低钙血症性扩张型心肌病病例。

病例报告

我们介绍一名41岁女性的病例,她在2018年甲状腺切除术后继发甲状旁腺功能减退。她接受了左甲状腺素、骨化三醇以及钙和维生素D补充剂治疗。2021年5月感染新冠病毒后,她的甲状旁腺功能减退失代偿,导致严重低钙血症,且治疗不当。五个月后,她出现呼吸困难、端坐呼吸和双侧下肢水肿加重。临床检查显示Chvostek征和Trousseau征阳性,提示严重低钙血症。心电图显示窦性心动过速伴QT延长,超声心动图显示左心室扩张,射血分数(EF)为29%。尽管冠状动脉造影正常,但CT扫描显示双侧胸腔积液和上腔静脉血栓形成。实验室检查结果证实存在低钙血症,磷升高,甲状旁腺激素水平降低。静脉补钙和心力衰竭治疗使症状在一周内得到改善,血清钙恢复正常。超声心动图显示逐渐恢复,8周时EF提高到38%,6个月后提高到57%。

讨论

钙在心脏收缩中起关键作用,其缺乏会严重影响心肌功能。甲状腺切除术后的低钙血症是一种已知并发症,在新冠病毒等全身感染期间可能会恶化。虽然低钙血症性心肌病经适当治疗可逆转,但需要早期识别和积极纠正。

结论

本病例强调了监测甲状旁腺功能减退患者钙水平的重要性,尤其是在全身感染的情况下,以预防低钙血症性心肌病等潜在危及生命的并发症。正确诊断和治疗低钙血症可使心脏功能完全恢复。

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