Dieck G S, Kelsey J L
Prev Med. 1985 Jan;14(1):63-9. doi: 10.1016/0091-7435(85)90021-0.
The relationships between certain reproductive, demographic, and medical variables and the carpal tunnel syndrome were examined using data from a hospital-based case-control study of women ages 45 to 74 years in the New Haven and Hartford, Connecticut, areas from 1977 to 1979. Characteristics of 40 carpal tunnel syndrome cases and 1,043 controls from hospital surgical services were compared. A history of diabetes was associated with an increased frequency of occurrence of the carpal tunnel syndrome, a finding consistent with clinical observation. Recent weight gain and use of estrogen replacement therapy were identified as possible risk factors; this provides some support for the theory that fluid retention in the soft tissues of the carpal tunnel is etiologically involved, although these results are preliminary and further research must be carried out to refute or support these findings. The negative association of the carpal tunnel syndrome with height and a history of varicose veins and the positive association with age at menopause cannot be explained and need verification.
利用1977年至1979年在康涅狄格州纽黑文和哈特福德地区对45至74岁女性进行的一项基于医院的病例对照研究数据，研究了某些生殖、人口统计学和医学变量与腕管综合征之间的关系。比较了来自医院外科服务的40例腕管综合征病例和1043例对照的特征。糖尿病史与腕管综合征的发生频率增加有关，这一发现与临床观察一致。近期体重增加和使用雌激素替代疗法被确定为可能的危险因素；这为腕管软组织中液体潴留与病因有关的理论提供了一些支持，尽管这些结果是初步的，必须进行进一步研究以反驳或支持这些发现。腕管综合征与身高、静脉曲张病史的负相关以及与绝经年龄的正相关无法解释，需要验证。
