Kaplan Yuksel, Kurt Semiha G, Karaer Hatice
Gaziosmanpasa University Faculty of Medicine, Department of Neurology, Tokat, Turkey.
J Neurol Sci. 2008 Jul 15;270(1-2):77-81. doi: 10.1016/j.jns.2008.02.003. Epub 2008 Mar 6.
Hormonal changes that accompany menopause have a significant impact on the nervous and other physiological systems. Our objective was to evaluate the relationship between carpal tunnel syndrome (CTS) and the clinical features of menopause in postmenopausal women, in comparison to age-matched healthy controls.
Overall, 6230 women were seen during the study period. Of these, 5587 were not eligible because they were premenopausal or perimenopausal. 537 women did not meet the criteria used in the study for a diagnosis of idiopathic CTS and were excluded. Finally, one hundred and six patients with CTS and 115 controls were examined. The presence of CTS was confirmed both clinically and electrophysiologically. Socio-demographic variables and reproductive histories were evaluated via a structured interview.
In comparison to healthy controls, patients with CTS showed a significantly greater number of pregnancies and an earlier age at menopause. Regarding the type of menopause, patients and controls showed similar frequencies for natural versus surgical menopause. The frequency of natural menopause was significantly higher than that of surgical menopause in both groups.
Our results suggest that age at menopause may be a significant factor in the development of CTS. Pregnancy-related hormonal changes may have long-term effects that increase the incidence of CTS in postmenopausal women.
绝经伴随的激素变化对神经及其他生理系统有重大影响。我们的目的是评估绝经后女性腕管综合征（CTS）与绝经临床特征之间的关系，并与年龄匹配的健康对照进行比较。
在研究期间共诊治了6230名女性。其中，5587名不符合条件，因为她们处于绝经前或围绝经期。537名女性不符合本研究中特发性CTS的诊断标准而被排除。最终，对106例CTS患者和115名对照进行了检查。通过临床和电生理检查确诊CTS。通过结构化访谈评估社会人口统计学变量和生殖史。
与健康对照相比，CTS患者的妊娠次数明显更多，绝经年龄更早。关于绝经类型，患者和对照在自然绝经与手术绝经的频率上相似。两组中自然绝经的频率均显著高于手术绝经。
我们的结果表明，绝经年龄可能是CTS发生的一个重要因素。与妊娠相关的激素变化可能具有长期影响，增加绝经后女性CTS的发病率。
