Evleksiz Demet, Gungor Abuzer, Karımzada Gardashkhan, Yaman Betul, Kara Aynaz A, Izci Yusuf, Weninger Wolfgang J, Türe Uğur
Department of Neurosurgery, Yeditepe University School of Medicine, İstanbul, Türkiye; Department of Neurosurgery, Hitit University, Erol Olcok Education and Research Hospital, Corum, Türkiye.
Department of Neurosurgery, Yeditepe University School of Medicine, İstanbul, Türkiye; Department of Neurosurgery, Istinye University, Faculty of Medicine, İstanbul, Türkiye.
World Neurosurg. 2025 Jun;198:124045. doi: 10.1016/j.wneu.2025.124045. Epub 2025 May 8.
The claustrum, a thin layer of gray matter between the insular cortex and putamen, has been a subject of anatomical and functional curiosity for centuries. Although early anatomical descriptions provide some insights, modern neuroimaging and neurosurgical studies have reignited interest in its structure and function. This study examines the historical evolution of the claustrum's terminology and clinical significance.
A comprehensive review was conducted, analyzing neuroanatomical texts from the 15th to 20th centuries and contemporary academic publications on the claustrum. The investigation focused on anatomical descriptions, variations in nomenclature, and the claustrum's neurosurgical significance.
The first known depiction of the claustrum appeared in the work of Vicq d'Azyr (1786), followed by formal naming as the vormauer (claustrum) by Burdach (1822). Subsequent terminology included N. taeniaeformis (Arnold, 1838) and avant-mur (Dejerine, 1895). Neurodevelopmental research by Puelles (2017, 2022) provided genetic evidence distinguishing it from adjacent structures. Functionally, Crick and Koch (2005) proposed its role in consciousness as a sensory integrator. Still, Yaşargil's neurosurgical observations indicate that tumor invasion or iatrogenic damage of the claustrum in cases of insular glioma does not result in impaired consciousness, prompting a reassessment of its functional role.
This review synthesizes historical and contemporary perspectives to highlight the claustrum's relevance in neuroscience and neurosurgery. Although its exact function remains debated, ongoing research continues to shed light on its role in brain connectivity and integration. Understanding the claustrum's structure and function may lead to novel insights into sensory processing, cognition, and potential neurosurgical applications.
屏状核是岛叶皮质和壳核之间的一层灰质薄板，几个世纪以来一直是解剖学和功能学上令人好奇的对象。尽管早期的解剖学描述提供了一些见解，但现代神经影像学和神经外科研究重新激发了人们对其结构和功能的兴趣。本研究考察了屏状核术语的历史演变及其临床意义。
进行了一项全面的综述，分析了15世纪至20世纪的神经解剖学文献以及当代关于屏状核的学术出版物。研究重点在于解剖学描述、命名法的变化以及屏状核在神经外科中的意义。
屏状核的首次已知描述出现在维克·德阿齐尔（1786年）的著作中，随后布尔达赫（1822年）将其正式命名为vormauer（屏状核）。后续术语包括带状核（阿诺德，1838年）和前壁（德热里纳，1895年）。普埃莱斯（2017年、2022年）的神经发育研究提供了将其与相邻结构区分开来的遗传学证据。在功能方面，克里克和科赫（2005年）提出其作为感觉整合器在意识中发挥作用。然而，亚萨吉尔的神经外科观察表明，岛叶胶质瘤病例中屏状核的肿瘤侵袭或医源性损伤并不会导致意识受损，这促使人们重新评估其功能作用。
本综述综合了历史和当代观点，以突出屏状核在神经科学和神经外科中的相关性。尽管其确切功能仍存在争议，但正在进行的研究继续揭示其在脑连接和整合中的作用。了解屏状核的结构和功能可能会为感觉处理、认知以及潜在的神经外科应用带来新的见解。
