Fletcher-McGruder B L, Gerritsen G C
Proc Soc Exp Biol Med. 1985 Oct;180(1):92-7. doi: 10.3181/00379727-180-42148.
Prediabetic Chinese hamsters were treated with antilymphocyte serum (ALS), or thymectomized in order to test the hypothesis that beta-cell loss leading to diabetes in this animal model was related to cell-mediated autoimmunity. In addition, passive transfer of diabetes from the Chinese hamster to the nude mouse was attempted by transplantation of lymphocytes. Treatment of prediabetic Chinese hamsters with ALS or thymectomy did not alter development or severity of diabetes in this animal model. Lymphocytes from newly diagnosed diabetic Chinese hamsters did not cause hyperglycemia in nude mice. These three lines of evidence suggest that cell-mediated autoimmunity does not contribute to the etiology of diabetes in the Chinese hamster. The Chinese hamster remains a good model for the study of those forms of diabetes not related to cell-mediated autoimmune phenomena.
对处于糖尿病前期的中国仓鼠进行抗淋巴细胞血清（ALS）治疗或胸腺切除，以检验在该动物模型中导致糖尿病的β细胞损失与细胞介导的自身免疫有关这一假设。此外，尝试通过淋巴细胞移植将中国仓鼠的糖尿病被动转移至裸鼠。用ALS治疗处于糖尿病前期的中国仓鼠或对其进行胸腺切除，并未改变该动物模型中糖尿病的发展或严重程度。新诊断出糖尿病的中国仓鼠的淋巴细胞并未使裸鼠出现高血糖。这三条证据表明，细胞介导的自身免疫与中国仓鼠糖尿病的病因无关。中国仓鼠仍是研究那些与细胞介导的自身免疫现象无关的糖尿病类型的良好模型。
