Gishizky M L, Frankel B J, Grodsky G M
Acta Physiol Scand. 1984 May;121(1):81-4. doi: 10.1111/j.1748-1716.1984.tb10460.x.
To assess the immune system's involvement in the causation of diabetes in the genetically diabetic Chinese hamster, "prediabetic" animals were immunosuppressed with cyclophosphamide, starting several weeks prior to the expected onset of hyperglycemia. The immunosuppressant dose was titrated to maximally depress the lymphocyte count without significant deleterious effects on food consumption, body weight or granulocyte count. Immunosuppression did not prevent or postpone the development of hyperglycemia or glucosuria. This suggests that if there is an autoimmune component in the etiology of diabetes in the genetically diabetic Chinese hamster, it takes place earlier or is of a more specific nature than that investigated in the present study.
为了评估免疫系统在遗传性糖尿病中国仓鼠糖尿病发病过程中的作用，在预期高血糖发作前几周开始，用环磷酰胺对“糖尿病前期”动物进行免疫抑制。免疫抑制剂剂量经过调整，以最大程度降低淋巴细胞计数，同时对食物消耗、体重或粒细胞计数无明显有害影响。免疫抑制并未预防或推迟高血糖或糖尿的发展。这表明，如果遗传性糖尿病中国仓鼠糖尿病病因中存在自身免疫成分，那么其发生时间比本研究中所调查的更早或具有更特殊的性质。
