Lau John, Tan Ken-Soon
School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
School of Medicine, Griffith University, Brisbane, Queensland, Australia.
BMJ Case Rep. 2025 May 8;18(5):e261002. doi: 10.1136/bcr-2024-261002.
A woman in her 50s contracted COVID-19 and initially presented a few weeks afterwards with left eye pain and redness. She was diagnosed with uveitis and treated with glucocorticoid eye drops. Renal impairment was found on laboratory investigations performed following the diagnosis of uveitis, and urine testing showed proteinuria. Serological testing showed no cause for the new findings, and renal imaging was unremarkable. A renal biopsy was conducted and histology was consistent with tubulointerstitial nephritis. A diagnosis of tubulointerstitial nephritis with uveitis (TINU) was established, and she was given prednisolone, with resolution of proteinuria and improvement in renal function. While TINU is rare but well described in children, it can also uncommonly be a cause of renal impairment in adults post COVID-19 infection, similar to cases in children.
一名50多岁的女性感染了新冠病毒，最初在几周后出现左眼疼痛和发红。她被诊断为葡萄膜炎，并接受了糖皮质激素眼药水治疗。在葡萄膜炎诊断后的实验室检查中发现肾功能损害，尿液检测显示蛋白尿。血清学检测未发现新发现的病因，肾脏影像学检查无异常。进行了肾活检，组织学检查与肾小管间质性肾炎一致。诊断为伴有葡萄膜炎的肾小管间质性肾炎（TINU），给予泼尼松龙治疗后，蛋白尿消失，肾功能改善。虽然TINU在儿童中罕见但有充分描述，但它在成人新冠病毒感染后也可能罕见地导致肾功能损害，类似于儿童病例。
