阿拉伯联合酋长国的肾小管间质性肾炎和葡萄膜炎综合征
Tubulointerstitial Nephritis and Uveitis Syndrome in the United Arab Emirates.
作者信息
Pichi Francesco, Aljeneibi Shaikha, Neri Piergiorgio
机构信息
Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
出版信息
Ocul Immunol Inflamm. 2024 Jul;32(5):578-582. doi: 10.1080/09273948.2023.2178939. Epub 2023 Feb 15.
PURPOSE
To report the first series of tubulointerstitial nephritis (TINU) syndrome from the Middle East.
METHODS
We retrospectively included patients with elevated urine beta-2 microglobulin, and a diagnosis of TINU based on anterior uveitis with or without posterior involvement. Multimodal imaging, duration of follow-up, local and systemic treatment used were recorded.
RESULTS
24 eyes of 12 patients (8 male, mean age 20.3 years) met the criteria for TINU. The most common posterior segment clinical finding was optic nerve head edema (41.7%), while on fluorescein angiography 58.3% and 75% of eyes had peripheral vascular and optic disc leakage, respectively. The mean follow-up was 2.5 years and all patients required immunomodulatory treatment.
CONCLUSIONS
Middle Eastern patients with TINU seem to have a male predominance, a bimodal distribution in terms of age, and present with ocular involvement first. Multimodal imaging is paramount in detecting subclinical inflammation and tailoring immunomodulatory treatment.
目的
报告中东地区首例肾小管间质性肾炎（TINU）综合征系列病例。
方法
我们回顾性纳入了尿β-2微球蛋白升高且基于前部葡萄膜炎伴或不伴后部受累诊断为TINU的患者。记录多模态影像学检查结果、随访时间、所采用的局部和全身治疗方法。
结果
12例患者（8例男性，平均年龄20.3岁）的24只眼符合TINU标准。最常见的后段临床发现是视神经乳头水肿（41.7%），而在荧光素血管造影检查中，分别有58.3%和75%的眼睛出现周边血管渗漏和视盘渗漏。平均随访时间为2.5年，所有患者均需要免疫调节治疗。
结论
中东地区的TINU患者似乎以男性为主，年龄呈双峰分布，且首先出现眼部受累。多模态影像学检查对于检测亚临床炎症和制定免疫调节治疗方案至关重要。
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