Gi signaling controls microglial surveillance and neuronal synchronization.

Microglia-neuron interactions are essential for maintaining brain homeostasis. In a recent study, Zhao and colleagues demonstrated that activation of Gi-G-protein-coupled receptors (Gi-GPCRs) on microglia suppresses microglial process dynamics, reduces neuronal activity, and disrupts network synchronization. These findings highlight the role of microglial Gi-GPCR signaling in neuromodulation and its role in network activity in the healthy brain.