Parati E A, Parenti M, Locatelli V, Penalva A, Tamminga C, Müller E E
Pharmacol Res Commun. 1985 May;17(5):407-15. doi: 10.1016/0031-6989(85)90075-x.
Withdrawal from chronic haloperidol exposure was associated to unaltered circulating levels of prolactin (PRL), decreased 3H-spiperone binding sites in the anterior pituitary and increased 3H-spiperone binding sites in the striatum of male rats. Haloperidol (0.1 mg/kg ip) induced similar rises in plasma PRL in haloperidol-or saline-treated rats and the dose of 0.01 mg/kg was ineffective in both groups. These findings illustrate the poor relatedness existing at the pituitary D2 receptor between biochemical and functional indices.
长期暴露于氟哌啶醇后戒断，雄性大鼠血清催乳素（PRL）水平未发生改变，垂体前叶3H-螺哌隆结合位点减少，纹状体3H-螺哌隆结合位点增加。氟哌啶醇（0.1mg/kg腹腔注射）可使氟哌啶醇或生理盐水处理的大鼠血浆PRL水平产生相似的升高，0.01mg/kg的剂量对两组均无效。这些发现表明垂体D2受体的生化指标和功能指标之间相关性较差。
