Di Paolo T, Daigle M, Labrie F
Psychoneuroendocrinology. 1984;9(4):399-404. doi: 10.1016/0306-4530(84)90047-7.
The effect of chronic haloperidol and estradiol treatments on dopamine receptors independent from the pituitary has been studied in ovariectomized (ovx) and hypophysectomized (hypox) rats. The striatal dopamine receptor density (Bmax) of hypox rats as measured with [3H]spiperone binding was increased after chronic estradiol or haloperidol treatment, while receptor affinity was unchanged. In hypox rats, estradiol given during withdrawal from haloperidol decreased the characteristic increase in dopamine receptor density observed upon withdrawal from this neuroleptic, while the estrogen was ineffective when given concomitantly with haloperidol. These results in hypox rats are similar to those observed in ovx rats, suggesting that haloperidol and estradiol influence striatal dopamine function independently of the pituitary.
在去卵巢（ovx）和垂体切除（hypox）的大鼠中，研究了长期使用氟哌啶醇和雌二醇对独立于垂体的多巴胺受体的影响。用[3H]螺哌隆结合法测量，长期使用雌二醇或氟哌啶醇后，hypox大鼠纹状体多巴胺受体密度（Bmax）增加，而受体亲和力不变。在hypox大鼠中，从氟哌啶醇撤药期间给予雌二醇可降低撤药时观察到的多巴胺受体密度的特征性增加，而雌激素与氟哌啶醇同时给予时则无效。hypox大鼠的这些结果与ovx大鼠中观察到的结果相似，表明氟哌啶醇和雌二醇独立于垂体影响纹状体多巴胺功能。
