Senf H J
Pharmazie. 1985 May;40(5):331-2.
A method for the determination of theophylline and promethazine in suppositories is proposed which allows the determination of both components in a single suppositorium. The ingredients were extracted by hot water and addition of a little bit of sulfuric acid. Theophylline is determined potentiometrically without separation of promethazine by titrating the acid which is set free after addition of silver nitrate. Promethazine is separated by ether in alkaline medium, reextracted in HCl (0,1 mol/l) and determined colorimetrically. The precision of both methods is good. The results of the determination in the suppositories are given.
提出了一种测定栓剂中茶碱和异丙嗪的方法，该方法可在单个栓剂中同时测定两种成分。通过热水和加入少量硫酸来提取成分。在不分离异丙嗪的情况下，通过滴定加入硝酸银后释放出的酸，用电位法测定茶碱。异丙嗪在碱性介质中用乙醚分离，再用0.1mol/L盐酸反萃取，然后用比色法测定。两种方法的精密度都很好。给出了栓剂的测定结果。
