Rahmouni Eya, Sakhri Saida, Allani Amira, Sahraoui Ghada, Ayadi Mohamed Ali, Dhiab Tarek Ben
Department of Surgical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Department of Surgical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Int J Surg Case Rep. 2025 Jun;131:111416. doi: 10.1016/j.ijscr.2025.111416. Epub 2025 May 8.
Gastric squamous cell carcinoma (GSCC) is a rare condition. We present the case of a locally advanced GSCC with dissociated response after neoadjuvant chemotherapy.
We present the case of a 34-year-old female patient who presented with a two-month history of epigastric pain and vomiting. Esophagogastroduodenoscopy identified a fundic lesion. Biopsy revealed a GSCC. CT scan showed a locally advanced expansile nodular process on the greater curvature of the stomach. Due to the locally advanced nature of the tumor, surgery was deemed excessively mutilating, and chemotherapy was initiated. The endoscopic evaluation showed complete resolution of the fundic mass. CT imaging demonstrated a 37 % reduction in the volume of target lesions. The patient subsequently underwent diagnostic laparoscopy, revealing a locally advanced unresectable tumor accompanied by diffuse peritoneal carcinomatosis. Palliative chemotherapy was initiated. The patient passed away two months after surgery.
GSCC is a rare condition. The exact origin of this tumor remains unclear. Clinically, GSCC presents similarly to other gastric tumors. Due to its rarity, there is no consensus on the optimal treatment for primary gastric squamous cell carcinoma, and the existing evidence is primarily based on case reports and small case series. Radical surgical excision with lymph node dissection remains the primary therapeutic approach. While neoadjuvant chemotherapy appears beneficial and effective, the available data remain limited. GSCC is known for its locally aggressive behavior and poor short-term prognosis.
Additional research is crucial to establish the most effective treatment strategies.
胃鳞状细胞癌（GSCC）是一种罕见疾病。我们报告一例局部晚期GSCC患者，其在新辅助化疗后出现分离反应。
我们报告一例34岁女性患者，有两个月的上腹部疼痛和呕吐病史。食管胃十二指肠镜检查发现胃底病变。活检显示为GSCC。CT扫描显示胃大弯处有一个局部晚期的膨胀性结节状病变。由于肿瘤的局部晚期性质，手术被认为会造成过度毁损，因此开始化疗。内镜评估显示胃底肿块完全消退。CT成像显示靶病变体积缩小了37%。患者随后接受了诊断性腹腔镜检查，发现是局部晚期不可切除的肿瘤，并伴有弥漫性腹膜癌转移。于是开始进行姑息化疗。患者在手术后两个月去世。
GSCC是一种罕见疾病。这种肿瘤的确切起源尚不清楚。临床上，GSCC的表现与其他胃肿瘤相似。由于其罕见性，对于原发性胃鳞状细胞癌的最佳治疗方法尚无共识，现有证据主要基于病例报告和小病例系列。根治性手术切除加淋巴结清扫仍然是主要的治疗方法。虽然新辅助化疗似乎有益且有效，但可用数据仍然有限。GSCC以其局部侵袭性和较差的短期预后而闻名。
开展更多研究对于确定最有效的治疗策略至关重要。
