Kilic Erhan, Bergel Ceyda Colakoglu-, Eryilmaz Isil Ezgi, Oguz-Akarsu Emel, Egeli Unal, Erer-Ozbek Cigdem Sevda, Sigirli Deniz, Balaban Rumeysa Fatma, Bulut Ebrucan, Cecener Gulsah, Zarifoglu Mehmet, Karli Hamdi Necdet
Neurology Department, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Medical Biology Department, Graduate School of Health Sciences, Bursa Uludag University, Bursa, Turkey.
Neurol Res. 2025 Aug;47(8):698-709. doi: 10.1080/01616412.2025.2497480. Epub 2025 May 10.
Based on the frequency of attacks, migraine is classified into two subtypes: episodic (EM) and chronic (CM). Migraine progression from EM to CM is supposed to be affected by various factors, which is known as "migraine chronification. However, the pathophysiology of migraine chronification is multifactorial and still not fully understood. Ion channels are hypothesized to play a role in migraine pathophysiology and are essential for generating and suppressing action potentials, which lie under the pain and related symptoms. Two sodium channel genes, and , have been reported to be associated with various pain sensitivities. Studies have shown that patients with EM and CM are more sensitive to chronic pain and that pain sensitivity may be a risk factor for chronification. Thus, the current study aimed to determine whether pain sensitivity-related and polymorphisms affect the EM-to-CM transition.
For this purpose, genotyping was performed using TaqMan SNP Assay for the (i) rs7595255, rs12622743, and rs11898284, (ii) rs6795970, rs6801957 SNPs in Turkish EM and CM patients.
The results showed that and polymorphisms did not play a role in the development of chronicity. However, the results indicated that the rs6795970 polymorphism was associated with osmophobia ( = 0.036).
rs6795970 polymorphism may be necessary to predict the EM-to-CM transition and identify therapeutic targets. However, further studies are required to confirm the osmophobia association of the rs6795970 polymorphism and to investigate the role of these SNPs in chronification.
根据发作频率，偏头痛分为两种亚型：发作性（EM）和慢性（CM）。偏头痛从EM进展为CM被认为受多种因素影响，这被称为“偏头痛慢性化”。然而，偏头痛慢性化的病理生理学是多因素的，仍未被完全理解。离子通道被认为在偏头痛病理生理学中起作用，并且对于产生和抑制动作电位至关重要，而动作电位是疼痛及相关症状的基础。据报道，两个钠通道基因与多种疼痛敏感性相关。研究表明，EM和CM患者对慢性疼痛更敏感，并且疼痛敏感性可能是慢性化的一个危险因素。因此，本研究旨在确定与疼痛敏感性相关的基因多态性是否会影响从EM到CM的转变。
为此，使用TaqMan SNP分析对土耳其EM和CM患者的（i）基因的rs7595255、rs12622743和rs11898284，（ii）基因的rs6795970、rs6801957进行基因分型。
结果表明，基因多态性在慢性化发展中不起作用。然而，结果表明基因的rs6795970多态性与畏光症相关（P = 0.036）。
rs6795970多态性可能对于预测从EM到CM的转变和确定治疗靶点是必要的。然而，需要进一步研究来证实基因的rs6795970多态性与畏光症的关联，并研究这些单核苷酸多态性在慢性化中的作用。
