Ruifrok A C, Kanon B, Konings A W
Radiat Res. 1985 Sep;103(3):452-4.
When the potassium content of LM mouse fibroblasts was determined 16 hr after a heat treatment, a correlation was found between the concentration of potassium in the cell population and the level of cellular survival. When the cells were made thermotolerant, the degree of acquired heat resistance corresponded to a higher level of residual potassium. Also the degree of heat protection by erythritol corresponded to a higher level of residual potassium in the cells, while heat sensitization by procaine resulted in a lower level of potassium. It is concluded that the amount of residual potassium in these cells measured 16 hr after heat treatment may be considered as a suitable index for cell survival after hyperthermia treatment under different conditions.
在对LM小鼠成纤维细胞进行热处理16小时后测定其钾含量时，发现细胞群体中的钾浓度与细胞存活水平之间存在相关性。当细胞产生热耐受性时，获得的耐热程度与较高水平的残余钾相对应。同样，赤藓糖醇的热保护程度也与细胞中较高水平的残余钾相对应，而普鲁卡因引起的热敏化则导致钾水平降低。得出的结论是，热处理16小时后测量的这些细胞中的残余钾量可被视为不同条件下热疗后细胞存活的合适指标。
