Viuff Jakob Hansen, Martiny Søren Korsgaard, Fuglsang Cecilia Hvitfeldt, Kristensen Frederik Pagh Bredahl, Pedersen Lars, Sørensen Henrik Toft
Department of Clinical Epidemiology, Center for Population Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
Department of Clinical Epidemiology, Center for Population Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
J Thromb Haemost. 2025 May 9. doi: 10.1016/j.jtha.2025.04.027.
Venous thromboembolism (VTE) has both short- and long-term health impacts. Knowledge about self-rated health (SRH) in survivors of VTE remains scarce.
We examined the prevalence of poor SRH in VTE survivors compared with that in persons without VTE.
We conducted a prevalence study using the Better Health in Late Life cohort of Danish residents aged 50 to 65 years, enrolled between 2021 and 2022. Participants completed an online questionnaire, and the data were linked to Danish population-based health registries. Information on previous VTE diagnosis was retrieved from the Danish National Patient Registry. Using modified Poisson regression models, we estimated adjusted prevalence proportion ratios (PRs) and prevalence proportion differences to quantify differences in the prevalence of poor SRH among VTE survivors and persons without VTE.
Our study included 113 658 individuals, among whom 2633 (2.3%) were VTE survivors. The prevalence of poor SRH was 31.6% in VTE survivors and 16.2% in participants without VTE, corresponding to a 1.85 (95% CI, 1.75-1.96) times higher prevalence of poor SRH. Compared with people without VTE, the PR was highest in VTE survivors with pulmonary embolism or provoked VTE. The PR remained elevated in comorbidity strata and in those diagnosed with VTE >10 years before questionnaire completion.
VTE survivors had nearly a 2-fold increased prevalence of poor SRH compared with those without VTE. This association persisted across VTE subtypes, comorbidity strata, and in those with a distant VTE diagnosis, suggesting long-term implications of VTE on SRH.
静脉血栓栓塞症（VTE）对健康有短期和长期影响。关于VTE幸存者自评健康（SRH）的知识仍然匮乏。
我们研究了VTE幸存者中SRH较差的患病率，并与无VTE者进行比较。
我们使用2021年至2022年招募的50至65岁丹麦居民的晚年健康状况更好队列进行了一项患病率研究。参与者完成了一份在线问卷，数据与丹麦基于人群的健康登记处相关联。先前VTE诊断的信息从丹麦国家患者登记处获取。使用改良的泊松回归模型，我们估计了调整后的患病率比例比（PRs）和患病率比例差异，以量化VTE幸存者和无VTE者中SRH较差的患病率差异。
我们的研究包括113658人，其中2633人（2.3%）为VTE幸存者。VTE幸存者中SRH较差的患病率为31.6%，无VTE的参与者中为16.2%，SRH较差的患病率高出1.85倍（95%CI，1.75 - 1.96）。与无VTE的人相比，患有肺栓塞或诱因性VTE的VTE幸存者的PR最高。在合并症分层以及在问卷完成前10年以上被诊断为VTE的人群中，PR仍然升高。
与无VTE者相比，VTE幸存者中SRH较差的患病率增加了近两倍。这种关联在VTE亚型、合并症分层以及有远期VTE诊断的人群中均持续存在，表明VTE对SRH有长期影响。
