使用鞘内靶向给药系统治疗C5 - 7水平颈椎脊髓损伤患者的重度疼痛——病例报告
Treatment of severe pain in a patient with a cervical spinal cord injury at C5-7 level using an intrathecal targeted drug delivery system - A case report.
作者信息
Yoo Yeong-Min, Jung Ji-Eun, Kim Hyun-Jin, Park Hyeon-Soo, Kim Hye-Jin, Byeon Gyeong-Jo
机构信息
Department of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
出版信息
Anesth Pain Med (Seoul). 2025 Apr;20(2):160-165. doi: 10.17085/apm.24151. Epub 2025 Apr 30.
BACKGROUND
Patients with cervical spinal cord injury (SCI) can experience pain refractory to aggressive multimodal therapies. Here, we report the use of an intrathecal targeted drug delivery (ITDD) system to treat severe pain in patients with cervical SCI.
CASE
A 64-year-old male patient underwent spinal cord stimulation (SCS) for severe cervical SCI. We proceeded with the ITDD system, placing the catheter tip at the C6 level. After placement of the ITDD system, the patient was monitored for regular refills of morphine sulfate in the drug delivery reservoir every 6 months. We reduced the oral morphine equivalent dose from nearly 333.8 mg/day to 133.8 mg/day.
CONCLUSIONS
The ITDD system may be a useful treatment option for patients with cervical SCI who have failed conventional treatments and do not show improvement with SCS.
背景
颈髓损伤（SCI）患者可能会经历对积极的多模式治疗无效的疼痛。在此，我们报告使用鞘内靶向药物递送（ITDD）系统治疗颈髓损伤患者的严重疼痛。
病例
一名64岁男性患者因严重颈髓损伤接受脊髓刺激（SCS）治疗。我们采用了ITDD系统，将导管尖端置于C6水平。放置ITDD系统后，每6个月对患者进行监测，定期在药物输送储器中补充硫酸吗啡。我们将口服吗啡等效剂量从近333.8毫克/天降至133.8毫克/天。
结论
对于传统治疗失败且脊髓刺激无改善的颈髓损伤患者，ITDD系统可能是一种有用的治疗选择。
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