Fan Haixia, Gao Jie, Chen Qian, Sun Shuangshuang, Guo Jinshen, Liu Xiaodong, Li Jinhu
First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Academy of Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, China.
Front Neurosci. 2025 Aug 25;19:1652196. doi: 10.3389/fnins.2025.1652196. eCollection 2025.
Spinal cord injury (SCI) often leads to severe motor and sensory impairments, and current treatment methods have not achieved complete neural repair. In recent years, exosomes have become a research focus in the treatment of nerve injuries due to their important roles in intercellular information transfer, immune regulation, and neural repair. Our study conducts a scientometric analysis to map the research landscape related to exosomes in SCI.
Articles and reviews related to exosome in SCI were retrieved from the Web of Science Core Collection and Scopus. Analysis was conducted using Microsoft Excel 2021, CiteSpace (6.4.R1), VOSviewer (1.6.18), the R software (4.4.3) bibliometrix package, etc.
Since 2018, the number of publications has rapidly increased. Fan Jin is the most academically influential author in the field, while Cai Weihua's research has received widespread recognition from researchers. China is the leading contributor among the 32 countries/regions. Among the 708 institutions, Central South University and Zhejiang University are the primary supporters. is the most influential journal in this field, with and also making significant contributions. Keyword analysis focuses on "mesenchymal stem cells," "inflammation," "cell therapy," "axonal regeneration," "functional recovery," "neuroinflammation," "neurodegeneration," "ferroptosis," "pyroptosis," and "precision medicine" emphasizing cellular therapies for tissue repair. Emerging topics like "nanoparticles" show significant potential in SCI treatment, further enhancing regenerative medicine approaches.
Our study show that the growing global interest in exosome-based therapies for SCI, marking an important step in understanding their preclinical potential. These therapies show promise in promoting neuroprotection, axonal regeneration, and modulating inflammation. Moving forward, future research will focus on further exploring the integration of exosome therapies with advanced drug delivery systems and regenerative medicine, aiming to enhance SCI treatments and tailor recovery strategies in preclinical models.
脊髓损伤（SCI）常导致严重的运动和感觉障碍，目前的治疗方法尚未实现完全的神经修复。近年来，外泌体因其在细胞间信息传递、免疫调节和神经修复中的重要作用，已成为神经损伤治疗的研究热点。我们的研究进行了科学计量分析，以描绘与SCI中外泌体相关的研究概况。
从科学引文索引核心合集和Scopus数据库中检索与SCI中外泌体相关的文章和综述。使用Microsoft Excel 2021、CiteSpace（6.4.R1）、VOSviewer（1.6.18）、R软件（4.4.3）的bibliometrix包等进行分析。
自2018年以来，出版物数量迅速增加。范进是该领域学术影响力最大的作者，而蔡卫华的研究得到了研究人员的广泛认可。在32个国家/地区中，中国是主要贡献者。在708个机构中，中南大学和浙江大学是主要支持者。 是该领域最具影响力的期刊， 和 也做出了重要贡献。关键词分析集中在“间充质干细胞”、“炎症”、“细胞治疗”、“轴突再生”、“功能恢复”、“神经炎症”、“神经退行性变”、“铁死亡”、“焦亡”和“精准医学”，强调用于组织修复的细胞治疗。“纳米颗粒”等新兴主题在SCI治疗中显示出巨大潜力，进一步增强了再生医学方法。
我们的研究表明，全球对基于外泌体的SCI治疗的兴趣日益增加，这标志着在了解其临床前潜力方面迈出了重要一步。这些治疗方法在促进神经保护、轴突再生和调节炎症方面显示出前景。展望未来，未来的研究将集中在进一步探索外泌体治疗与先进药物递送系统和再生医学的整合，旨在加强SCI治疗并在临床前模型中定制恢复策略。
