Craik Rachel, Akuze Joseph, Volvert Marie-Laure, Blencowe Hannah, Mukhanya Moses, Makanga Prestige Tatenda, Tchavana Corssino, Moore Sophie E, Vala Anifa, Koech Angela, Tribe Rachel M, Noble Alison, Bah Baboucar, D'Alessandro Umberto, Vidler Marianne, Tu Domena, Maculuve Sonia, Wanje Onesmus, Idris Yahaya, Mwashigadi Grace, Ochieng Marvin, Filippi Veronique, Roca Anna, Magee Laura A, Poston Lucilla, Mistry Hiten D, Bah Yorro, Li Jing, Temmerman Marleen, Sevene Esperanca, Jah Hawanatu, Mwadime Emily, Barratt Ben, Papageorghiou Aris T, Makacha Liberty, Quimice Lazaro, Touray Fatima, Salisbury Tatiana, Kongira Fatoumata, von Dadelszen Peter
Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
BMJ Open. 2025 May 11;15(5):e091831. doi: 10.1136/bmjopen-2024-091831.
The PREgnancy Care Integrating translational Science, Everywhere Network was established to investigate specific placental disorders (pregnancy hypertension, preterm birth, fetal growth restriction and stillbirth) in sub-Saharan Africa. We created a repository of clinical and social data with associated biological samples from pregnant and non-pregnant women. Alongside this, local infrastructure and expertise in the field of maternal and child health research were enhanced.
Pregnant women were recruited in participating health facilities in The Gambia, Kenya and Mozambique at their first antenatal visit or at the time a placental disorder was diagnosed (Kenya and The Gambia only). Follow-up study visits were conducted in the third trimester, delivery and 6 weeks to 6 months postpartum. To elucidate the difference between pregnancy and non-pregnancy biology in these settings, non-pregnant nulliparous and parous women, aged 16-49 years, were recruited opportunistically primarily from family planning clinics in Kenya and Mozambique, and randomly through the Health and Demographic Surveillance System in The Gambia. Non-pregnant participants only had one study visit. Biological samples were processed rapidly and locally, stored initially in liquid nitrogen and then at -80°C, and details entered into an OpenSpecimen database linked to their social determinants and clinical research data.
A total of 6932 pregnant and 1825 non-pregnant women were recruited to the study, providing a repository of clinical and social data and a biorepository of 482 448 samples. To date, baseline descriptive analysis of the cohort has been undertaken, as well as a substudy on the prevalence of COVID-19 in the cohort.
Analysis of data and samples will include an analysis of biomarker and social and physical determinants of health and how these interact in a systemic approach to understanding the origins of common placental disorders. The data from non-pregnant women will provide control data for comparison with the data from normal and complicated pregnancies. Findings will be disseminated to local stakeholders and communities through meetings and ongoing community engagement and globally by publication and presentations at scientific meetings.
建立“妊娠保健整合转化科学全球网络”（PREgnancy Care Integrating translational Science, Everywhere Network），以调查撒哈拉以南非洲地区的特定胎盘疾病（妊娠高血压、早产、胎儿生长受限和死产）。我们创建了一个包含孕妇和非孕妇临床及社会数据以及相关生物样本的资料库。与此同时，加强了母婴健康研究领域的当地基础设施和专业知识。
在冈比亚、肯尼亚和莫桑比克的参与研究的医疗机构，孕妇在首次产前检查时或被诊断出胎盘疾病时（仅在肯尼亚和冈比亚）被招募。在孕晚期、分娩时以及产后6周至6个月进行随访研究。为了阐明这些情况下妊娠与非妊娠生物学之间的差异，年龄在16 - 49岁的未孕未育和已育非孕妇主要从肯尼亚和莫桑比克的计划生育诊所中机会性招募，并通过冈比亚的健康与人口监测系统随机招募。非孕妇参与者仅进行一次研究访问。生物样本在当地迅速处理，最初储存在液氮中，然后在-80°C下储存，详细信息录入与她们的社会决定因素和临床研究数据相关联的OpenSpecimen数据库。
共有6932名孕妇和1825名非孕妇被纳入该研究，提供了一个临床和社会数据资料库以及一个包含482448个样本的生物样本库。迄今为止，已对该队列进行了基线描述性分析，以及一项关于该队列中新冠病毒感染率的子研究。
对数据和样本的分析将包括对健康的生物标志物、社会和身体决定因素以及它们如何以系统方法相互作用以理解常见胎盘疾病起源的分析。来自非孕妇的数据将提供对照数据，以便与正常和复杂妊娠的数据进行比较。研究结果将通过会议和持续的社区参与传播给当地利益相关者和社区，并通过在科学会议上发表和展示在全球范围内传播。
