Mehta S, Kalsi H K, Nain C K, Menkes J H
Pediatr Res. 1977 Apr;11(4):290-3. doi: 10.1203/00006450-197704000-00006.
Cerebral blood flow (CBF) and carbohydrate metabolism were studied in 5 normal children and 25 children, aged 40 months or less, with varying degrees of protein-calorie malnutrition (PCM). CBF in normal children and those suffering from grade I PCM was 90.3 +/- 5.7 ml/100 g/min, a value comparable with that obtained by other investigators, but the proportion of glucose taken up by the brain which combined with oxygen, the oxygen/glucose index (OGI), was 65.8%, indicating significant conversion of glucose into lactic acid. Cerebral lactic acid production was 45.3 micronM/100 g/min, and the respiratory quotient (R.Q.) was 1.00. With increasing severity of PCM, there was increased glucose utilization and a progressive reduction in the OGI. In grade IV PCM, CBF was 68.7 +/- 5.4ml/100g/min, and the OGI was 34.7%. Cerebral lactic acid production was 27.4 micronM/100 g/min, and the R.Q. rose to 1.52. These findings suggest that in severe human PCM the proportion of glucose undergoing aerobic oxidation is reduced, and that in addition to being converted to lactic acid, a significant proportion of glucose is transformed by the brain into long chain fatty acids.
对5名正常儿童和25名年龄在40个月及以下、患有不同程度蛋白质 - 热量营养不良（PCM）的儿童进行了脑血流量（CBF）和碳水化合物代谢研究。正常儿童和患有I级PCM的儿童的脑血流量为90.3±5.7 ml/100 g/分钟，该值与其他研究者所得结果相当，但大脑摄取的与氧气结合的葡萄糖比例，即氧/葡萄糖指数（OGI）为65.8%，表明葡萄糖大量转化为乳酸。脑乳酸生成量为45.3微摩尔/100 g/分钟，呼吸商（R.Q.）为1.00。随着PCM严重程度的增加，葡萄糖利用率增加，OGI逐渐降低。在IV级PCM中，脑血流量为68.7±5.4 ml/100 g/分钟，OGI为34.7%。脑乳酸生成量为27.4微摩尔/100 g/分钟，R.Q.升至1.52。这些发现表明，在严重的人类PCM中，进行有氧氧化的葡萄糖比例降低，并且除了转化为乳酸外，相当一部分葡萄糖被大脑转化为长链脂肪酸。
