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透析患者的肠道微生物群动态：对并发症和治疗的影响。

Gut microbiome dynamics of patients on dialysis: implications for complications and treatment.

作者信息

Li Changlin, Lin Xiaomeng, Li Yuting, Duan Jiamin, Cai Xudong

机构信息

Department of Nephrology, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, China.

Ningbo Institute of Chinese Medicine Research, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, China.

出版信息

Front Pharmacol. 2025 Apr 25;16:1470232. doi: 10.3389/fphar.2025.1470232. eCollection 2025.

DOI:10.3389/fphar.2025.1470232
PMID:40351408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12062584/
Abstract

The gut microbiome plays a significant role in dialysis. As disease progresses, the choice of dialysis method and dietary habits change, and the diversity and richness of the gut microbiome in patients on dialysis change as well. The uremic toxins produced exacerbate inflammatory responses and oxidative stress, leading to markedly different incidence rates of complications such as cardiovascular disease and dialysis-associated peritonitis among patients on dialysis. The intake of probiotics, prebiotics, synbiotics, and natural medicines during daily life can regulate the gut microbiome, reduce the production of uremic toxins in patients on dialysis. This review found that the occurrence of complications in dialysis patients is related to changes in the gut microbiome and the accumulation of uremic toxins. The use of probiotics, prebiotics, synbiotics, and natural medicines can improve these conditions and reduce the incidence of dialysis-related complications.

摘要

肠道微生物群在透析中起着重要作用。随着疾病进展，透析方法的选择和饮食习惯会发生变化，透析患者肠道微生物群的多样性和丰富度也会改变。所产生的尿毒症毒素会加剧炎症反应和氧化应激，导致透析患者中诸如心血管疾病和透析相关性腹膜炎等并发症的发病率显著不同。日常生活中摄入益生菌、益生元、合生元和天然药物可调节肠道微生物群，减少透析患者体内尿毒症毒素的产生。本综述发现，透析患者并发症的发生与肠道微生物群的变化和尿毒症毒素的蓄积有关。使用益生菌、益生元、合生元和天然药物可改善这些状况并降低透析相关并发症的发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/12062584/a354f42897f3/fphar-16-1470232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/12062584/86d572ada26a/fphar-16-1470232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/12062584/a2fdf8935728/fphar-16-1470232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/12062584/a354f42897f3/fphar-16-1470232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/12062584/86d572ada26a/fphar-16-1470232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/12062584/a2fdf8935728/fphar-16-1470232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/12062584/a354f42897f3/fphar-16-1470232-g003.jpg

相似文献

[1]
Gut microbiome dynamics of patients on dialysis: implications for complications and treatment.

Front Pharmacol. 2025-4-25

[2]
Impact of Gut Microbiome Modulation on Uremic Toxin Reduction in Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis.

Nutrients. 2025-4-3

[3]
Synbiotics, prebiotics and probiotics for people with chronic kidney disease.

Cochrane Database Syst Rev. 2023-10-23

[4]
The Microbiome and Uremic Solutes.

Toxins (Basel). 2022-3-30

[5]
Protein-bound uremic toxin lowering strategies in chronic kidney disease: a systematic review and meta-analysis.

J Nephrol. 2021-12

[6]
Gut Microbiota and Cardiovascular Uremic Toxicities.

Toxins (Basel). 2018-7-11

[7]
The Impact of CKD on Uremic Toxins and Gut Microbiota.

Toxins (Basel). 2021-3-31

[8]
The Impact of Synbiotic Treatment on the Levels of Gut-Derived Uremic Toxins, Inflammation, and Gut Microbiome of Chronic Kidney Disease Patients-A Randomized Trial.

J Ren Nutr. 2023-3

[9]
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Clin J Am Soc Nephrol. 2016-2-5

[10]
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Cochrane Database Syst Rev. 2022-9-20

引用本文的文献

[1]
Peritoneal Dialysis -Associated Fibrosis: Emerging Mechanisms and Therapeutic Opportunities.

Front Pharmacol. 2025-8-22

本文引用的文献

[1]
Synbiotics, prebiotics and probiotics for people with chronic kidney disease.

Cochrane Database Syst Rev. 2023-10-23

[2]
Why are we Not Getting More Patients onto Peritoneal Dialysis? Observations From the United States with Global Implications.

Kidney Int Rep. 2023-7-25

[3]
Metagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease.

Genome Biol. 2023-10-12

[4]
Dietary fatty acids intake and all-cause and cardiovascular mortality in patients on peritoneal dialysis.

Clin Nutr. 2023-11

[5]
Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis.

FASEB J. 2023-9

[6]
Pea hull fiber supplementation does not modulate uremic metabolites in adults receiving hemodialysis: a randomized, double-blind, controlled trial.

Front Nutr. 2023-6-30

[7]
The probiotic Zhang-mediated correction of gut dysbiosis ameliorates peritoneal fibrosis by suppressing macrophage-related inflammation the butyrate/PPAR-γ/NF-κB pathway.

Food Funct. 2023-7-31

[8]
Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota.

Acta Pharm Sin B. 2023-4

[9]
Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis.

JAMA Netw Open. 2023-5-1

[10]
Detailing Protein-Bound Uremic Toxin Interaction Mechanisms with Human Serum Albumin in the Pursuit of Designing Competitive Binders.

Int J Mol Sci. 2023-4-18

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