Liu Yang, Yang Jie, Yu Fenghua, Li Li, Zhao Ning, Lu Cheng, Lu Aiping, He Xiaojuan
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
Front Pharmacol. 2025 Apr 25;16:1528671. doi: 10.3389/fphar.2025.1528671. eCollection 2025.
Hepatocellular carcinoma (HCC) has a relatively poor prognosis and a high degree of malignancy. However, the therapeutic drugs are limited. In recent years, abnormal lipid metabolism and its important role in HCC has been reported, and emerging studies found that some formulae and active components of traditional Chinese medicine (TCM) can regulate abnormal lipid metabolism in HCC, showing their good application prospects. Therefore, this article summarizes the changes and the roles of lipid metabolites in HCC progression, and discusses the role of formulae and active components of TCM for the treatment of HCC based on their regulation on abnormal lipid metabolism. A deeper understanding of their relationship may help the precise use of these formulae and active components in HCC.
肝细胞癌（HCC）预后相对较差，恶性程度高。然而，其治疗药物有限。近年来，有报道称脂质代谢异常及其在HCC中的重要作用，并且新出现的研究发现一些中药配方和活性成分可以调节HCC中的异常脂质代谢，显示出良好的应用前景。因此，本文总结了脂质代谢产物在HCC进展中的变化及其作用，并基于其对异常脂质代谢的调节作用，探讨了中药配方和活性成分在HCC治疗中的作用。对它们之间关系的更深入理解可能有助于这些配方和活性成分在HCC中的精准应用。
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