Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drug Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China.
Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drug Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China.
Chin J Nat Med. 2022 Jul;20(7):481-493. doi: 10.1016/S1875-5364(22)60206-1.
TCM formulae are the important guidances for clinical application of traditional Chinese medicines, which follow the principles of diagnosis and treatment in TCM. Elucidating the bio-active components of TCM formulae is the key to the modernization and internationalization of traditional Chinese medicines. With the rapid development of modern instruments and technology, many new theories, methods and strategies are emerging, which upgrade the research of TCM formulae into a higher level. Only when the medicinal efficacy, bio-active components, function mechanism of TCM formulae are understood, we can guarantee TCM safety and quality control. In this paper, we summarized the latest modern research thoughts and methods on bio-active components of TCM formulae including formula decomposition study, serum pharmacology and serum pharmacochemistry, association analysis, biochromatography, network pharmacology, metabolomics and proteomics, so as to provide reference for the research and development of TCM in the future.
中药方剂是临床应用中药的重要指导，遵循中医的诊断和治疗原则。阐明中药方剂的生物活性成分是中药现代化和国际化的关键。随着现代仪器和技术的快速发展，许多新的理论、方法和策略正在涌现，将中药方剂的研究提升到更高的水平。只有了解中药方剂的药效、生物活性成分和作用机制，才能保证中药的安全性和质量控制。本文总结了中药方剂生物活性成分的最新现代研究思路和方法，包括方剂分解研究、血清药理学和血清药物化学、关联分析、生物色谱法、网络药理学、代谢组学和蛋白质组学，为中药的研究和开发提供参考。
