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隐匿性甲状腺乳头状癌伴肱骨近端孤立性附属骨转移——病例报告

Occult Papillary Carcinoma Thyroid with Solitary Appendicular Bone Metastasis in Proximal Humerus - A Case Report.

作者信息

Kantiwal Prabodh, Prakash Vimal, Yadav Sandeep Kumar, Elhence Abhay, Aggarwal Aakarsh, Khera Sudeep

机构信息

Department of Orthopaedics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

出版信息

J Orthop Case Rep. 2025 May;15(5):85-90. doi: 10.13107/jocr.2025.v15.i05.5566.

DOI:10.13107/jocr.2025.v15.i05.5566
PMID:40351619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12064254/
Abstract

INTRODUCTION: An occult presentation of primary thyroid malignancy refers to a clinically silent primary tumor that initially manifests through metastasis or secondary paraneoplastic phenomena. Papillary carcinoma is a well-recognized thyroid malignancy associated with this pattern of presentation, but bone metastases are uncommon in occult papillary thyroid carcinoma (OPTC), with reported cases typically involving the axial skeleton. CASE REPORT: A woman in her 70s presented with swelling and pain in her right arm. Examination revealed an oval swelling on the proximal humerus. Radiographs and magnetic resonance images suggested a lytic lesion in the proximal humerus. Upon metastatic workup, biopsy, and immunohistochemistry, the diagnosis turned out to be metastasis from occult papillary thyroid cancer. CONCLUSION: Bone metastases are uncommon in OPTC, with reported cases typically involving the axial skeleton. Metastasis to the appendicular skeleton as the initial presentation is exceptionally rare.

摘要

引言：原发性甲状腺恶性肿瘤的隐匿性表现是指临床上无症状的原发性肿瘤，最初通过转移或继发性副肿瘤现象表现出来。乳头状癌是一种与这种表现模式相关的公认的甲状腺恶性肿瘤，但隐匿性乳头状甲状腺癌（OPTC）发生骨转移并不常见，报告的病例通常累及中轴骨骼。 病例报告：一名70多岁的女性因右臂肿胀和疼痛就诊。检查发现肱骨近端有椭圆形肿胀。X线片和磁共振成像显示肱骨近端有溶骨性病变。经过转移灶检查、活检和免疫组化，诊断为隐匿性乳头状甲状腺癌转移。 结论：OPTC发生骨转移并不常见，报告的病例通常累及中轴骨骼。以四肢骨骼转移作为首发表现极为罕见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/b7f5053fc922/JOCR-15-85-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/5de9d0fe7e69/JOCR-15-85-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/1df5ae846bb0/JOCR-15-85-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/4ba70467746f/JOCR-15-85-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/b6eff470b4e9/JOCR-15-85-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/b7f5053fc922/JOCR-15-85-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/5de9d0fe7e69/JOCR-15-85-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/1df5ae846bb0/JOCR-15-85-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/4ba70467746f/JOCR-15-85-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/b6eff470b4e9/JOCR-15-85-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/12064254/b7f5053fc922/JOCR-15-85-g005.jpg

相似文献

[1]
Occult Papillary Carcinoma Thyroid with Solitary Appendicular Bone Metastasis in Proximal Humerus - A Case Report.

J Orthop Case Rep. 2025-5

[2]
Bony Metastasis to the Radius as the Initial Presentation of a Lung Adenocarcinoma.

Cureus. 2023-3-29

[3]
Solitary pulmonary metastasis from occult papillary thyroid carcinoma.

Thorac Cancer. 2015-7-15

[4]
Papillary thyroid carcinoma presenting as a primary renal tumor with multiple pulmonary and bone metastases: a case report.

J Med Case Rep. 2019-4-20

[5]
Solitary cystic lymph neck node metastasis of occult thyroid papillary carcinoma.

Med Oral Patol Oral Cir Bucal. 2008-12-1

[6]
[Occult papillary carcinoma of the thyroid presenting as a solitary pulmonary metastasis].

Nihon Naibunpi Gakkai Zasshi. 1991-6-20

[7]
Occult papillary carcinoma of the thyroid with distant metastases.

Cancer. 1984-9-15

[8]
A double mutation of BRAF L597Q and V600E in situ and solitary brain metastasis of occult papillary thyroid carcinoma: A case report.

Medicine (Baltimore). 2021-2-12

[9]
[A case of occult thyroid cancer detected as a solitary nodular lung metastasis].

Nihon Kokyuki Gakkai Zasshi. 2008-7

[10]
Papillary thyroid microcarcinoma with contralateral large humerus metastasis and cervical lymph node metastasis: A case report.

Front Oncol. 2022-8-10

本文引用的文献

[1]
Mandibular metastasis of follicular thyroid carcinoma: A case report along with the concise review of literature.

J Oral Maxillofac Pathol. 2022

[2]
Bone metastasis and skeletal-related events in patients with solid cancer: A Korean nationwide health insurance database study.

PLoS One. 2020-7-17

[3]
Genetic profile of advanced thyroid cancers in relation to distant metastasis.

Endocr Relat Cancer. 2020-5

[4]
Bone metastases in thyroid cancer.

J Bone Oncol. 2020-2-19

[5]
Understanding the Bone in Cancer Metastasis.

J Bone Miner Res. 2018-11-26

[6]
Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review.

BMC Cancer. 2017-3-28

[7]
Unusual Thyroid Carcinoma Metastases: a Case Series and Literature Review.

Endocr Pathol. 2016-3

[8]
[Lymph node and distant metastases of thyroid gland cancer. Metastases in the thyroid glands].

Pathologe. 2015-11

[9]
Bone metastasis and the metastatic niche.

J Mol Med (Berl). 2015-11

[10]
Occult papillary thyroid carcinoma metastasis to the sacrum and the skull: an unusual presentation.

Case Rep Med. 2014

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