Suolang Yuzhen, Gao Yizhu, Sun Changli, Zhang Shu
Department of Emergency Medicine, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China.
Disaster Medical Center, Sichuan University, 610041 Chengdu, Sichuan, China.
Rev Cardiovasc Med. 2025 Apr 18;26(4):26347. doi: 10.31083/RCM26347. eCollection 2025 Apr.
Our study evaluated the prognostic significance of white blood cells (WBC) count and WBC subsets in relation to the risk of mortality in acute aortic dissection (AAD) patients during their hospital stay.
We included 833 patients with AAD in this retrospective study. The primary outcome was in-hospital mortality. Cox regression analysis was employed to determine the independent risk factors for mortality in patients with AAD. Amidst the low- and high-WBC groups, we use Kaplan‒Meier survival analysis to compare the cumulative survival rates of patients with AAD.
Within 342 patients with type A AAD, patients belonging to the high-WBC group exhibited a notably higher mortality rate compared to patients in the low-WBC group. Kaplan-Meier analysis exhibited that the patients in high-WBC patients had a significantly higher mortality rate. Multivariable Cox regression analysis demonstrated that an elevated WBC was an independent impact factor of in-hospital mortality of patients with type A AAD (hazard ratio, 2.01; 95% confidence interval (CI): 1.24 to 3.27; = 0.005). Corresponding outcomes were witnessed in 491 patients with type B AAD.
An elevated WBC count was strongly correlated with an elevated risk of mortality in hospitalized patients afflicted with either type A or type B AAD.
我们的研究评估了急性主动脉夹层（AAD）患者住院期间白细胞（WBC）计数及WBC亚群与死亡风险的预后意义。
本回顾性研究纳入833例AAD患者。主要结局为院内死亡率。采用Cox回归分析确定AAD患者死亡的独立危险因素。在低WBC组和高WBC组中，我们使用Kaplan-Meier生存分析比较AAD患者的累积生存率。
在342例A型AAD患者中，高WBC组患者的死亡率显著高于低WBC组患者。Kaplan-Meier分析显示，高WBC患者的死亡率显著更高。多变量Cox回归分析表明，WBC升高是A型AAD患者院内死亡的独立影响因素（风险比，2.01；95%置信区间（CI）：1.24至3.27；P = 0.005）。在491例B型AAD患者中也观察到了相应结果。
WBC计数升高与A型或B型AAD住院患者的死亡风险升高密切相关。
