Guechchati Mouna, Baybay Hanane, Zeryouhi Meryem, Tahiri Elousrouti Layla, Mernissi FatimaZahra
Department of Dermatology, University Hospital Hassan II, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdellah University, Fez, MAR.
Department of Pathology, University Hospital Hassan II, Faculty of Medicine, Pharmacy and Dental Medicine, Sidi Mohamed Ben Abdellah University, Fez, MAR.
Cureus. 2025 Apr 11;17(4):e82079. doi: 10.7759/cureus.82079. eCollection 2025 Apr.
Hydroa vacciniforme (HV) is a rare, chronic photodermatosis linked to Epstein-Barr virus (EBV) infection. We report a 12-year-old child with recurrent vesiculobullous facial lesions and photosensitivity for six years. Clinical examination revealed hemorrhagic crusts with atrophic scars. Dermoscopy showed whitish streaks and rosettes. Histopathology demonstrated epidermal spongiosis and a dense dermal lymphoid infiltrate. Immunohistochemistry confirmed CD3+, CD5+, CD7+, and CD8+ lymphocytes, with granzyme B and perforin expression, but no CD56. EBV serology was positive. Differential diagnoses, including cutaneous lupus, leishmaniasis, and porphyria, were excluded. The patient was managed with strict photoprotection, leading to sustained remission over two years. Early diagnosis and sun protection are essential for managing HV, as seen in our case.
种痘样水疱病（HV）是一种罕见的慢性光皮肤病，与爱泼斯坦-巴尔病毒（EBV）感染有关。我们报告一名12岁儿童，面部反复出现水疱大疱性皮损并伴有光敏反应6年。临床检查发现有出血性结痂及萎缩性瘢痕。皮肤镜检查显示有白色条纹和玫瑰花结。组织病理学显示表皮海绵形成和密集的真皮淋巴样浸润。免疫组化证实有CD3 +、CD5 +、CD7 +和CD8 +淋巴细胞，伴有颗粒酶B和穿孔素表达，但无CD56。EBV血清学检查呈阳性。排除了包括皮肤狼疮、利什曼病和卟啉病在内的鉴别诊断。该患者通过严格的光防护进行治疗，两年多来病情持续缓解。如我们的病例所示，早期诊断和防晒对于种痘样水疱病的治疗至关重要。
