Strano A, Avellone G, Novo S, Davì G, Di Garbo V
Ric Clin Lab. 1985;15 Suppl 1:179-84.
In 40 patients suffering from chronic ischemic heart disease (16 with history of myocardial infarction, 10 with unstable angina and 14 with stable angina) and in an equal number of sex-and age-matched control subjects, we have determined plasma and blood viscosity according to RAND et al. using a Wells-Brookfield Micro-Viscometer, shear rate 230 sec-1, and red cell filterability according to REID et al. Significant differences were found in patients suffering from ischemic heart disease, in comparison with the control group, for blood viscosity (p less than 0.01), plasma viscosity (p less than 0.001) and red cell filterability (p less than 0.001). The changes of hemorheological parameters in ischemic heart disease, especially in patients suffering from unstable angina and in those with history of myocardial infarction, point to the opportunity of a pharmacological treatment aiming at improving the district microcirculation.
在40例慢性缺血性心脏病患者（16例有心肌梗死病史，10例为不稳定型心绞痛，14例为稳定型心绞痛）以及同等数量的性别和年龄匹配的对照受试者中，我们按照兰德等人的方法，使用韦尔斯-布鲁克菲尔德微型粘度计（剪切速率230秒-1）测定了血浆和血液粘度，并按照里德等人的方法测定了红细胞过滤性。与对照组相比，缺血性心脏病患者在血液粘度（p<0.01）、血浆粘度（p<0.001）和红细胞过滤性（p<0.001）方面存在显著差异。缺血性心脏病患者血液流变学参数的变化，尤其是不稳定型心绞痛患者和有心肌梗死病史的患者，提示有机会进行旨在改善局部微循环的药物治疗。
