地尔硫䓬改变血液流变学。
Diltiazem alters blood rheology.
作者信息
Ernst E, Matrai A
机构信息
Hemorheology Research Laboratory, University of Munich, Federal Republic of Germany.
出版信息
Pharmatherapeutica. 1988;5(4):213-6.
A study was carried out to investigate whether diltiazem influence blood rheology, as has been reported for some other calcium channel blockers. Twenty patients with clinical, stable angina pectoris were treated with 2 x 90 mg diltiazem per day for 2 weeks. Blood viscosity, plasma viscosity, haematocrit, blood cell filterability and red cell aggregation were taken as in vitro measures quantifying the flow properties of blood. After 1-week's treatment, low and middle shear blood viscosity had declined significantly. This change was more pronounced after 2-weeks' medication. At this point, there was also an increase in blood cell filterability. All other variables did not show significant alterations. The results suggest a significant fluidification of blood during diltiazem treatment. This effect may reduce the viscous component of the total peripheral resistance, and therefore, it may contribute to an increase in perfusion and to the anti-anginal properties of the drug.
开展了一项研究，以调查地尔硫䓬是否会像其他一些钙通道阻滞剂那样影响血液流变学。20例临床诊断为稳定型心绞痛的患者，每天服用2×90毫克地尔硫䓬，持续2周。血液粘度、血浆粘度、血细胞比容、血细胞过滤性和红细胞聚集性被作为体外测量指标，用于量化血液的流动特性。治疗1周后，低切变率和中切变率血液粘度显著下降。用药2周后这种变化更为明显。此时，血细胞过滤性也有所增加。所有其他变量均未显示出显著变化。结果表明，地尔硫䓬治疗期间血液显著液化。这种作用可能会降低总外周阻力的粘性成分，因此，它可能有助于增加灌注以及该药物的抗心绞痛特性。
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