de Figueiredo John M, Kohn Robert, Chung Joyce Y, Gostoli Sara
School of Medicine, Yale University, New Haven, CT, United States.
School of Public Health, Brown University, Providence, RI, United States.
Front Psychiatry. 2025 Apr 25;16:1554128. doi: 10.3389/fpsyt.2025.1554128. eCollection 2025.
This study aimed at identifying correlates of demoralization in breast cancer.
Information was obtained from outpatients with breast cancer at the Oncology Clinic of a university-affiliated hospital in the United States, using reliable and valid scales, and from the participants' medical records on demographic and social characteristics, location, type, and stage of cancer, whether it was a re-occurrence or first time diagnosed, type of cancer treatment, medications being used, history of mental disorder, functional impairment, perceived stress, perceived social support, resilience, subjective incompetence, demoralization, and depression. Demoralization was measured with the Demoralization Scale. Bivariable and multivariable analyses were conducted with demoralization as the dependent variable.
Demoralization correlated positively with functional impairment, perceived stress, depression, and subjective incompetence, and negatively with months since diagnosed with breast cancer, perceived social support, resilience, and quality of life. Forward stepwise regression conducted without depression in the regression equation identified emotional wellbeing subscale of quality of life, resilience, subjective incompetence, perceived social support, and functional impairment as significant. After forced entry of depression, perceived social support and mild depression ceased to be significant, leaving only moderate and severe depression as significant. Perceived stress did not enter any of the regression models.
Early detection of demoralization and of the co-occurrence of depression and demoralization are essential for promoting the well-being of patients with breast cancer. Psychotherapy should focus on strengthening the modifiable negative correlates of demoralization, countering the modifiable positive correlates, and preventing the co-occurrence of demoralization and depression.
本研究旨在确定乳腺癌患者中士气低落的相关因素。
从美国一家大学附属医院肿瘤门诊的乳腺癌门诊患者处获取信息,使用可靠且有效的量表,并从参与者的病历中获取有关人口统计学和社会特征、癌症的位置、类型和阶段、是否为复发或首次诊断、癌症治疗类型、正在使用的药物、精神障碍病史、功能损害、感知压力、感知社会支持、心理韧性、主观无能、士气低落和抑郁的信息。使用士气低落量表测量士气低落情况。以士气低落为因变量进行双变量和多变量分析。
士气低落与功能损害、感知压力、抑郁和主观无能呈正相关,与乳腺癌诊断后的月数、感知社会支持、心理韧性和生活质量呈负相关。在回归方程中不纳入抑郁进行的向前逐步回归分析确定,生活质量的情绪健康子量表、心理韧性、主观无能、感知社会支持和功能损害具有显著性。在强制纳入抑郁后,感知社会支持和轻度抑郁不再具有显著性,仅中度和重度抑郁具有显著性。感知压力未进入任何回归模型。
早期发现士气低落以及抑郁与士气低落的同时出现对于促进乳腺癌患者的福祉至关重要。心理治疗应侧重于加强士气低落的可改变负相关因素、对抗可改变的正相关因素,并预防士气低落和抑郁的同时出现。