Cordeiro Barbara Naeme de Lima, Rocha Jader Vinicius Da Silva, Kuster Elizangela, Thibauth Aurore, Nascimento Lucas Rodrigues, Swank Chad, Arêas Guilherme Peixoto Tinoco, da Silva Filho Walter Gomes, Anhoque Carolina Fiorin, Silva Paiva Wellingson, Buarque Jéssica Costa, Arêas Fernando Zanela
Neurorehabilitation and Neuromodulation Laboratory, Federal University of Espirito Santo, Vitória, Brazil.
Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium.
Front Hum Neurosci. 2025 Apr 25;19:1552387. doi: 10.3389/fnhum.2025.1552387. eCollection 2025.
The aim of this study is to report clinical cases of patients with severe traumatic brain injury (TBI) who underwent transcranial direct current stimulation (tDCS) in the subacute phase. We hypothesize that tDCS will improve the functional and cognitive recovery of patients. 5 men, admitted with severe TBI, and Glasgow Coma Scale (GCS) score ≤ 8 on admission or at some point during hospitalization, were in the subacute phase of the trauma (between 2 and 16 weeks). Participants received 5 sessions of tDCS every day. The results were measured at the beginning and at the end of the 5 sessions. The application of tDCS with an active electrode (anode) was applied to the region of the left dorsolateral prefrontal cortex (LPFC - F3) and the cathode was positioned over the contralateral supraorbital area. Clinical outcomes were measured through cognitive assessment, Mini Mental State Examination (MMSE), mental health and depression, Hospital Anxiety and Depression Scale (HADS-A), pain, visual analogue scale (VAS), Functional Independence Measure (FIM), Rancho Los Amigos Scale (RLAS) and Glasgow Outcome Scale - Extended (GOS-E), were applied to classify the patient's condition. For characteristics of participants and findings results, descriptive statistics were presented as mean ± Standard Deviation (SD). The results after the tDCS intervention show substantial improvement in the assessed. The research demonstrates the potential benefits of using tDCS in patients with TBI, but also provides a practical basis for applying these techniques in clinical settings.
本研究的目的是报告在亚急性期接受经颅直流电刺激（tDCS）的重度创伤性脑损伤（TBI）患者的临床病例。我们假设tDCS将改善患者的功能和认知恢复。5名因重度TBI入院且入院时或住院期间某个时间点格拉斯哥昏迷量表（GCS）评分≤8分的男性处于创伤亚急性期（2至16周）。参与者每天接受5次tDCS治疗。在5次治疗开始和结束时进行结果测量。将有源电极（阳极）的tDCS应用于左侧背外侧前额叶皮质（LPFC - F3）区域，阴极置于对侧眶上区域。通过认知评估、简易精神状态检查表（MMSE）、心理健康和抑郁、医院焦虑抑郁量表（HADS - A）、疼痛、视觉模拟量表（VAS）、功能独立性测量（FIM）及Rancho Los Amigos量表（RLAS）和格拉斯哥扩展预后量表（GOS - E）来测量临床结果，以对患者病情进行分类。对于参与者的特征和研究结果，描述性统计以均值±标准差（SD）表示。tDCS干预后的结果显示评估指标有显著改善。该研究证明了在TBI患者中使用tDCS的潜在益处，同时也为在临床环境中应用这些技术提供了实际依据。
