促甲状腺激素释放激素：行为兴奋的生理伴随物。

Thyrotropin-releasing hormone: physiological concomitants of behavioral excitation.

作者信息

Andry D K, Horita A

出版信息

Pharmacol Biochem Behav. 1977 Jan;6(1):55-9. doi: 10.1016/0091-3057(77)90159-9.

Abstract

Two doses (10 microng and 100 microng) of thyrotropin-releasing hormone (TRH) or saline were injected intraventricularly in rabbits pretreated with either saline, pentobarbital or phenobarbital. Behavior, EEG patterns, respiration rate and heart rate were monitored for 100 min posttreatment. TRH significantly altered all physiological indices except heart rate in both barbiturate- and saline-pretreated animals. The results support the contention that TRH modified central functioning by direct action. Results are discussed in terms of barbiturate antagonism and excitatory effects of TRH.

摘要

将两剂（10微克和100微克）促甲状腺激素释放激素（TRH）或生理盐水脑室注射到预先用生理盐水、戊巴比妥或苯巴比妥处理过的兔子体内。在处理后100分钟监测行为、脑电图模式、呼吸频率和心率。在巴比妥类药物和生理盐水预处理的动物中，TRH均显著改变了除心率外的所有生理指标。结果支持TRH通过直接作用改变中枢功能的观点。从巴比妥类药物的拮抗作用和TRH的兴奋作用方面对结果进行了讨论。