Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.
Department of Biomedical Informatics, CHA University School of Medicine, CHA University, Seongnam, South Korea.
Laryngoscope. 2023 Nov;133(11):3144-3151. doi: 10.1002/lary.30654. Epub 2023 Mar 10.
Accumulating evidence suggests that hearing impairment is associated with the onset of depression. However, large-scale epidemiological studies are required to define this association more clearly. We aimed to investigate the risk of new-onset depression in Korean older adults with and without hearing impairment.
From the National Health Insurance Service-Senior Cohort, which is a retrospective-prospective hybrid database, we analyzed data for 254,466 older adults enrolled in the Korea National Health Insurance Service-Senior Cohort who underwent at least one health screening between 2003 and 2019. A Cox proportional hazards regression model was used to evaluate the association between hearing impairment and the risk of incident depression, which was presented as adjusted hazard ratios (aHR) with 95% confidence intervals (CIs). All participants were followed up until the date of incident depression, death, or December 31, 2019.
During 3,417,682 person-years of follow-up investigation, hearing impairment was associated with a higher risk of incident depression (vs. no hearing impairment) in the final adjusted model (aHR, 1.11; 95% CI, 1.01-1.21; p = 0.033). Stratified analyses revealed a significant interaction among age, hearing impairment, and the risk of depression. Participants aged <65 years had a higher risk of depression (aHR, 1.29; 95% CI, 1.12-1.50; p < 0.001) than those aged 65 or above (aHR, 1.15; 95% CI, 1.01-1.30; p = 0.032).
Hearing impairment is independently associated with a higher risk of depression among older adults. The prevention and treatment of hearing impairment may aid in mitigating the risk of incident depression.
Level 3 Laryngoscope, 133:3144-3151, 2023.
越来越多的证据表明听力障碍与抑郁的发生有关。然而，需要大规模的流行病学研究来更清楚地定义这种关联。我们旨在调查韩国老年人群中有无听力障碍与新发抑郁症风险的关系。
我们从国家健康保险服务-老年人队列中进行了回顾性前瞻性混合数据库分析，该队列纳入了 2003 年至 2019 年间至少接受过一次健康筛查的 254466 名老年人。使用 Cox 比例风险回归模型评估听力障碍与新发抑郁风险之间的关系，结果以调整后的危险比（aHR）和 95%置信区间（CI）表示。所有参与者随访至新发抑郁、死亡或 2019 年 12 月 31 日。
在 3417682 人年的随访调查中，在最终调整模型中，听力障碍与新发抑郁风险较高相关（与无听力障碍相比）（aHR，1.11；95%CI，1.01-1.21；p=0.033）。分层分析显示年龄、听力障碍与抑郁风险之间存在显著的交互作用。年龄<65 岁的参与者发生抑郁的风险较高（aHR，1.29；95%CI，1.12-1.50；p<0.001），而年龄 65 岁或以上的参与者发生抑郁的风险较低（aHR，1.15；95%CI，1.01-1.30；p=0.032）。
听力障碍与老年人抑郁风险升高独立相关。听力障碍的预防和治疗可能有助于降低新发抑郁的风险。
3 级喉镜，133：3144-3151，2023。
